Intracellular zinc irritates TRPA1

被引：11
|
作者：
Banke, Tue G. [1 ]
Wickenden, Alan D. [1 ]
机构：
[1] Johnson & Johnson Pharmaceut Res & Dev LLC, San Diego, CA 92121 USA
来源：
NATURE CHEMICAL BIOLOGY | 2009年 / 5卷 / 03期
关键词：
D O I：
10.1038/nchembio0309-141
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Exposure to zinc can cause pain and inflammation and can be harmful to human health. New evidence suggests that activation of the irritant receptor, TRPA1, which is expressed on pain-sensing neurons, may be responsible for some of these symptoms of zinc toxicity.
引用
收藏
页码：141 / 142
页数：3
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