Intracellular zinc irritates TRPA1

被引：11

作者：

Banke, Tue G. ^{[1
]}

Wickenden, Alan D. ^{[1
]}

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev LLC, San Diego, CA 92121 USA

来源：

NATURE CHEMICAL BIOLOGY | 2009年 / 5卷 / 03期

关键词：

D O I：

10.1038/nchembio0309-141

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exposure to zinc can cause pain and inflammation and can be harmful to human health. New evidence suggests that activation of the irritant receptor, TRPA1, which is expressed on pain-sensing neurons, may be responsible for some of these symptoms of zinc toxicity.

引用

页码：141 / 142

页数：3

共 50 条

[31] Ethyl Vanillin Activates TRPA1
Wu, Shaw-wen
Fowler, Daniel K.
Shaffer, Forrest J.
Lindberg, Jonathon E. M.
Peters, James H.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2017, 362 (03): : 368 - 377
[32] TRPA1 modulators in preclinical development
Viana, Felix
Ferrer-Montiel, Antonio
EXPERT OPINION ON THERAPEUTIC PATENTS, 2009, 19 (12) : 1787 - 1799
[33] Roles of TRPA1 in Painful Dysesthesia
So, Kanako
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2020, 140 (01): : 1 - 6
[34] Ligustilide: a novel TRPA1 modulator
Jian Zhong
Federica Pollastro
Jean Prenen
Zhiming Zhu
Giovanni Appendino
Bernd Nilius
Pflügers Archiv - European Journal of Physiology, 2011, 462 : 841 - 849
[35] TRPA1 Contributes to Cold Hypersensitivity
del Camino, Donato
Murphy, Sarah
Heiry, Melissa
Barrett, Lee B.
Earley, Taryn J.
Cook, Colby A.
Petrus, Matt J.
Zhao, Michael
D'Amours, Marc
Deering, Nate
Brenner, Gary J.
Costigan, Michael
Hayward, Neil J.
Chong, Jayhong A.
Fanger, Christopher M.
Woolf, Clifford J.
Patapoutian, Ardem
Moran, Magdalene M.
JOURNAL OF NEUROSCIENCE, 2010, 30 (45): : 15165 - 15174
[36] Sensitization of TRPA1 by Protein Kinase A
Meents, Jannis E.
Fischer, Michael J. M.
McNaughton, Peter A.
PLOS ONE, 2017, 12 (01):
[37] TRPA1: irritant detector of the airways
Gerhold, K. A.
Bautista, D. M.
JOURNAL OF PHYSIOLOGY-LONDON, 2008, 586 (14): : 3303 - 3303
[38] Menthacarin® desensitizes TRPA1 channels
Sabrina, Weisenburger
Martin, Lehner D.
PLANTA MEDICA, 2021, 87 (15) : 1299 - 1299
[39] TRPA1 senses oxygen availability
Takahashi, Nobuaki
Kiyonaka, Shigeki
Numata, Tomohiro
Kozai, Daisuke
Mori, Yasuo
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, 118 : 10P - 10P
[40] The role of TRPA1 in pain and inflammation
Hogestatt, Edward D.
ACTA PHYSIOLOGICA, 2015, 215 : 30 - 30

← 1 2 3 4 5 →