A facile synthesis of 2,3-disubstituted furo[2,3-b]pyridines

被引：5
|
作者：
Beutner, Gregory L. [1 ]
Kuethe, Jeffrey T. [1 ]
Yasuda, Nobuyoshi [1 ]
机构：
[1] Merck & Co Inc, Dept Proc Res, Rahway, NJ 07065 USA
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 07期
关键词：
HIV PROTEASE INHIBITOR; PRACTICAL SYNTHESIS; KEY INTERMEDIATE; FUROPYRIDINES; POTENT; ALKALOIDS;
D O I：
10.1016/j.tetlet.2008.11.125
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In a three-step sequence starting from readily available starting materials, 2,3-carbon disubstituted furo[2,3-b]pyridines can be accessed in good yields and purity. Furo[2,3-b]pyridines bearing ester, amide and ketone groups at the 2-position can be prepared with a variety of aryl and alkyl groups at the 3-position. (C) 2008 Elsevier Ltd. All rights reserved.
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页码：781 / 784
页数：4
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