Facile Synthesis of Fluorinated Pyrrolo[2,3-b]pyridines

被引：1
|
作者：
Groth, Ulrich [1 ]
Iaroshenko, Viktor O.
Wang, Yan
Wesch, Thornas
机构：
[1] Univ Konstanz, Fachbereich Chem, D-78457 Constance, Germany
来源：
SYNLETT | 2009年 / 03期
关键词：
pyrrol; amine; fluorine; pyridine; annulation; electrophilic aromatic substitution; TRICYCLIC NUCLEOSIDE PHOSPHATE; EDITING ADENOSINE-DEAMINASE; ANALOGS; INHIBITION; DESIGN; CANCER; MODEL; TRIAL; HIV-1;
D O I：
10.1055/s-0028-1087530
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
With the purpose to synthesize novel ADAs (adenosine deaminase) and IMPDH (inosine 5'-monophosphate dehydrogenase) inhibitors the reaction of 5-amino-1-tert-butyl-1H-pyrrolo-3-carbonitrile with fluorinated 1,3-biselectrophiles was studied. An efficient and convenient synthetical approach to obtain fluorinated pyrrolo[2,3-b]pyridines was developed. tert-Butyl protecting group was successfully cleaved by treating of synthesized pyrrolo-pyridines with concentrated sulfuric acid.
引用
收藏
页码：456 / 460
页数：5
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