A facile synthesis of 2,3-disubstituted furo[2,3-b]pyridines

被引：5

作者：

Beutner, Gregory L. ^{[1
]}

Kuethe, Jeffrey T. ^{[1
]}

Yasuda, Nobuyoshi ^{[1
]}

机构：

[1] Merck & Co Inc, Dept Proc Res, Rahway, NJ 07065 USA

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 07期

关键词：

HIV PROTEASE INHIBITOR; PRACTICAL SYNTHESIS; KEY INTERMEDIATE; FUROPYRIDINES; POTENT; ALKALOIDS;

D O I：

10.1016/j.tetlet.2008.11.125

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In a three-step sequence starting from readily available starting materials, 2,3-carbon disubstituted furo[2,3-b]pyridines can be accessed in good yields and purity. Furo[2,3-b]pyridines bearing ester, amide and ketone groups at the 2-position can be prepared with a variety of aryl and alkyl groups at the 3-position. (C) 2008 Elsevier Ltd. All rights reserved.

引用

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页码：781 / 784

页数：4

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