Effect of phlorotannins from Sargassum thunbergii on blood lipids regulation in mice with high-fat diet

被引：5

作者：

Wei, Yuxi ^{[1
]}

Xu, Chuanjin ^{[2
]}

Liu, Qi ^{[3
]}

Xiao, Huihui ^{[1
]}

Zhao, Aiyun ^{[1
]}

Hu, Yingfen ^{[1
]}

Liu, Lei ^{[1
]}

Zhao, Ling ^{[1
]}

机构：

[1] Qingdao Univ, Dept Biol, Qingdao 266071, Peoples R China

[2] Qingdao Univ, Sch Med, Affiliated Hosp, Qingdao 266003, Peoples R China

[3] Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2012年 / 26卷 / 22期

关键词：

Sargassum thunbergii; phlorotannins; hypocholesterolemic activity; 3-hydroxy-3-methylglutaryl-coenzyme A; low density lipoprotein receptor; DENSITY-LIPOPROTEIN RECEPTOR;

D O I：

10.1080/14786419.2011.625500

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

On the basis of activity screening on blood lipid regulation by animal study, we chose high molecular weight phlorotannins from Sargassum thunbergii (HMPs) as a drug to explore the regulating mechanism. The results showed that HMPs could significantly decrease TC and TG levels (p < 0.05), and very significantly decrease LDL-C level (p < 0.01). Results of a hypocholesterolemic mechanism study showed that HMPs could obviously increase liver LDL-R level (p < 0.05), but the fact that they failed to block the synthesis of HMG-CoA reductase excludes a relevant influence on cellular cholesterol biosynthesis. We propose that HMPs from Sargassum thunbergii have a profound hypocholesterolemic effect and the mechanism relies mainly on the increase of LDL-R level in liver.

引用

页码：2117 / 2120

页数：4

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