Effect of phlorotannins from Sargassum thunbergii on blood lipids regulation in mice with high-fat diet

被引：5
|
作者：
Wei, Yuxi [1 ]
Xu, Chuanjin [2 ]
Liu, Qi [3 ]
Xiao, Huihui [1 ]
Zhao, Aiyun [1 ]
Hu, Yingfen [1 ]
Liu, Lei [1 ]
Zhao, Ling [1 ]
机构：
[1] Qingdao Univ, Dept Biol, Qingdao 266071, Peoples R China
[2] Qingdao Univ, Sch Med, Affiliated Hosp, Qingdao 266003, Peoples R China
[3] Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2012年 / 26卷 / 22期
关键词：
Sargassum thunbergii; phlorotannins; hypocholesterolemic activity; 3-hydroxy-3-methylglutaryl-coenzyme A; low density lipoprotein receptor; DENSITY-LIPOPROTEIN RECEPTOR;
D O I：
10.1080/14786419.2011.625500
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
On the basis of activity screening on blood lipid regulation by animal study, we chose high molecular weight phlorotannins from Sargassum thunbergii (HMPs) as a drug to explore the regulating mechanism. The results showed that HMPs could significantly decrease TC and TG levels (p < 0.05), and very significantly decrease LDL-C level (p < 0.01). Results of a hypocholesterolemic mechanism study showed that HMPs could obviously increase liver LDL-R level (p < 0.05), but the fact that they failed to block the synthesis of HMG-CoA reductase excludes a relevant influence on cellular cholesterol biosynthesis. We propose that HMPs from Sargassum thunbergii have a profound hypocholesterolemic effect and the mechanism relies mainly on the increase of LDL-R level in liver.
引用
收藏
页码：2117 / 2120
页数：4
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