Distribution of amantadine-resistant H5N1 avian influenza variants in Asia

被引：212
|
作者：
Cheung, Chung-Lam
Rayner, Jane M.
Smith, Gavin J. D.
Wang, Pui
Naipospos, T. S. P.
Zhang, Jinxia
Yuen, Kwok-Yung
Webster, Robert G.
Peiris, J. S. Malik
Guan, Yi
Chen, Honglin
机构：
[1] Univ Hong Kong, Fac Med, Dept Microbiol, State Key Lab Emerging Infect Dis, Hong Kong, Hong Kong, Peoples R China
[2] Shantou Univ, Coll Med, Joint Influenza Res Ctr, Shantou, Guangdong, Peoples R China
[3] St Jude Childrens Res Hosp, Div Virol, Dept Infect Dis, Memphis, TN 38105 USA
[4] Ctr Indonesian Vet Analyt Studies, Jakarta, Indonesia
来源：
JOURNAL OF INFECTIOUS DISEASES | 2006年 / 193卷 / 12期
关键词：
D O I：
10.1086/504723
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We examined the distribution of genetic mutations associated with resistance to the M2 ion channel-blocking adamantane derivatives, amantadine and rimantadine, among H5N1 viruses isolated in Vietnam, Thailand, Cambodia, Indonesia, Hong Kong, and China. More than 95% of the viruses isolated in Vietnam and Thailand contained resistance mutations, but resistant mutants were less commonly isolated in Indonesia (6.3% of isolates) and China (8.9% of isolates), where human infection was recently reported. The dual mutation motif Leu26Ile-Ser31Asn (leucine -> isoleucine at aa 26 and serine -> asparagine at aa 31) was found almost exclusively in all resistant isolates from Vietnam, Thailand, and Cambodia, suggesting the biological selection of these mutations.
引用
收藏
页码：1626 / 1629
页数：4
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