Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern China

被引：124
|
作者：
He, Guimei [1 ]
Qiao, Jian [1 ]
Dong, Changgui [1 ]
He, Cheng [1 ]
Zhao, Lihong [1 ]
Tian, Yong [1 ]
机构：
[1] China Agr Univ, Dept Pathophysiol, Coll Vet Med, Beijing 100094, Peoples R China
来源：
ANTIVIRAL RESEARCH | 2008年 / 77卷 / 01期
基金：
中国国家自然科学基金;
关键词：
amantadine-resistance; H5N1 avian influenza viruses; Northern China; M2; gene;
D O I：
10.1016/j.antiviral.2007.08.007
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We tested the amantadine-resistance among avian influenza A (H5N1) viruses isolated from chicken in Hebei Province of Northern China from 2001 to 2005, and investigated the amantadine use in this area. Plague reduction assay in MDCK cells showed that 83.3% isolates (5/6) were amantadine-resistant strains. The M2 sequence analysis revealed that four of five resistant isolates contained the point mutations (Ser to Asn) at position 31 that could confer resistance,to amantadine. These results indicated that the incidence of amantadine-resistant viruses isolated in Northern China was particularly high. In the investigation of amantadine use, we found that amantadine was used extensively in poultry farms in this area, which maybe was one of reasons of the high amantadine-resistance incidence. (C) 2007 Elsevier B.V. All rights reserved.
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收藏
页码：72 / 76
页数：5
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