Sustainable Synthetic Approaches for 3-Aminoimidazo-fused Heterocycles via Groebke-Blackburn-Bienayme Process

Two different sustainable and efficient synthetic methods have been developed for the synthesis of a variety of 3-aminoimidazo fused heterocycles by one-pot three component reaction of 2-aminoazines, aldehydes and isocyanides. The methods adopted were (a) aqueous micellar mediated condition (method A) (b) VB(1)catalyzed reaction under solvent-free condition (method B). Excellent yields were obtained for a broad range of biologically significant imidazopyridine core molecules under green conditions at room temperature. Synthesis in aqueous micellar medium, mild reaction conditions, organocatalyst, easy work-up and isolation, and gram scale synthesis, are some of the advantages of these protocols.