A highly efficient synthesis of imidazo-fused polyheterocycles via Groebke-Blackburn-Bienayme reaction catalyzed by LaCl3•7H2O

被引：37
|
作者：
Shinde, Anand H. [1 ]
Srilaxmi, Malipatel [1 ]
Satpathi, Bishnupada [1 ]
Sharada, Duddu S. [1 ]
机构：
[1] Indian Inst Technol IIT Hyderabad, Dept Chem, Ordnance Factory Estate, Yeddumailaram 502205, Telangana, India
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 43期
关键词：
Imidazo[1,2-a]pyridine; Lanthanum chloride-catalyzed; Solvent-free; Multicomponent reaction; MULTICOMPONENT SYNTHESIS; 3-COMPONENT REACTION; ANNULATED PYRIDINES; CHLORIDE; CONDENSATION; LEVAMISOLE; PYRAZINES; REAGENTS; BIOLOGY; AMINES;
D O I：
10.1016/j.tetlet.2014.08.126
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly efficient and mild protocol for the synthesis of imidazo-fused polyheterocycles via Groebke-Blackburn-Bienayme reaction under the influence of catalytic amount of lanthanum chloride heptahydrate has been described. A wide range of nitrogen-enriched polyheterocycles are synthesized with high yields under neat conditions. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5915 / 5920
页数：6
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