Diaminoimidazopyrimidines: Access via the Groebke-Blackburn-Bienayme Reaction and Structural Data Mining

Imidazopyrimidines with diverse substitution patterns are a prime class of heterocycles, present in many commercially available or late-stage clinical trials drugs. Here, we describe a fast access to diaminoimidazopyrimidines by means of a powerful multicomponent reaction; the Groebke-Blackburn-Bienayme reaction. We provide the design of such libraries of compounds, identifying all the structural motifs, and subsequently their synthesis. Scope and limitations are discussed, in addition to data mining in the Cambridge Structural Database and pharmacophore search with Crossminer. The presented approach highlights the vast amount of data available in the databases and provides potential future scaffold hopping alternatives for compounds with similar binding patterns. Further studies are ongoing to introduce more "drug-like" properties into this scaffold and to investigate cellular mechanism-based anti-cancer behaviours.