Heterologous production of polyketides by modular type I polyketide synthases in Escherichia coli

被引：33

作者：

Yuzawa, Satoshi ^{[1
,3
]}

Kim, Woncheol ^{[1
,3
]}

Katz, Leonard ^{[1
,4
]}

Keasling, Jay D. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Calif Berkeley, Inst QB3, Berkeley, CA 94270 USA

[2] Univ Calif Berkeley, Dept Chem & Biomol Engn, Berkeley, CA 94270 USA

[3] Joint BioEnergy Inst, Emeryville, CA 94608 USA

[4] Synthet Biol Engn Res Ctr, Emeryville, CA 94608 USA

[5] Lawrence Berkeley Natl Lab, Phys Biosci Div, Berkeley, CA 94270 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2012年 / 23卷 / 05期

基金：

美国国家科学基金会;

关键词：

AUTOTROPHIC CO2 FIXATION; 6-DEOXYERYTHRONOLIDE B SYNTHASE; ENZYME-SUBSTRATE INTERACTIONS; PROTEIN-PROTEIN INTERACTIONS; COENZYME-A REDUCTASE; 3-HYDROXYPROPIONATE CYCLE; ENGINEERED BIOSYNTHESIS; FUNCTIONAL-ANALYSIS; CHLOROFLEXUS-AURANTIACUS; RHODOBACTER-SPHAEROIDES;

D O I：

10.1016/j.copbio.2011.12.029

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Heterologous production of polyketide compounds, an important class of natural products with complex chemical structures, was first demonstrated with Streptomyces parvulus in 1984. Although Streptomyces strains are good first options for heterologous polyketide biosynthesis, their slow growth kinetics prompt other hosts to also be considered. Escherichia coli provides key elements of an ideal host in terms of the growth rate, culture conditions, and available recombinant DNA tools. Here we review the current status and potential for metabolic engineering of polyketides in E. coli.

引用

页码：727 / 735

页数：9

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