Heterologous production of coryneazolicin in Escherichia coli

被引：2

作者：

Takuma, Momoko ^{[1
]}

Kuroha, Mai ^{[1
]}

Nagano, Yuki ^{[1
]}

Kaweewan, Issara ^{[2
]}

Hemmi, Hikaru ^{[3
]}

Oyoshi, Takanori ^{[1
,4
]}

Kodani, Shinya ^{[1
,2
,4
]}

机构：

[1] Shizuoka Univ, Grad Sch Integrated Sci & Technol, Suruga Ku, 836 Ohya, Shizuoka 4228529, Japan

[2] Shizuoka Univ, Grad Sch Sci & Technol, Suruga Ku, 836 Ohya, Shizuoka 4228529, Japan

[3] NARO, Food Res Inst, 2-1-12 Kannondai, Tsukuba, Ibaraki 3058642, Japan

[4] Shizuoka Univ, Acad Inst, Suruga Ku, 836 Ohya, Shizuoka 4228529, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2019年 / 72卷 / 11期

基金：

日本学术振兴会;

关键词：

PROMOTES SECONDARY METABOLISM; MICROCIN B17; POSTTRANSLATIONAL MODIFICATIONS; CHEMICAL-SUBSTANCE; NATURAL-PRODUCTS; LASSO PEPTIDES; PLANTAZOLICIN; BIOSYNTHESIS; GOADSPORIN; STREPTOLYSIN;

D O I：

10.1038/s41429-019-0212-x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Coryneazolicin is a plantazolicin family peptide, belonging to linear azole-containing peptides (LAPs). Although coryneazolicin was previously synthesized by in vitro experiments, its biological activity has not been evaluated. In this report, the heterologous production of coryneazolicin was accomplished to obtain enough coryneazolicin for biological activity tests. The structure of coryneazolicin was confirmed by ESI-MS and NMR analyses. The biological activity tests indicated that coryneazolicin possessed potent antibacterial activity and cytotoxicity. Although antibacterial activity of plantazolicin was previously reported, cytotoxicity was newly found in coryneazolicin among plantazolicin type peptides. In addition, we revealed that coryneazolicin induced apoptosis on HCT116 and HOS cancer cell lines.

引用

页码：800 / 806

页数：7

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