Optimization of heterologous protein production in Escherichia coli

被引：123
|
作者：
Weickert, MJ [1 ]
Doherty, DH [1 ]
Best, EA [1 ]
Olins, PO [1 ]
机构：
[1] SOMATOGEN INC, BOULDER, CO 80301 USA
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 1996年 / 7卷 / 05期
关键词：
D O I：
10.1016/S0958-1669(96)80051-6
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Escherichia coli has long been the primary prokaryotic host for the synthesis of heterologous proteins. Recent advances have been made in the expression of complex proteins as soluble, functional molecules, complete with prosthetic groups, disulfide bonds, and quaternary structure. The development of alternative promoter and induction strategies has improved the options available for manipulating the expression conditions, which are frequently critical to soluble yield.
引用
收藏
页码：494 / 499
页数：6
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