A new diastereoselective multicomponent, one-pot strategy for the synthesis of 3-substituted isoindolinones via efficient C-C bond formation

被引：18

作者：

Wan, Jie-Ping ^{[1
]}

Zhou, Jing ^{[1
]}

Mao, Hui ^{[1
]}

Pan, Yuan-Jiang ^{[1
]}

Wu, An-Xin ^{[2
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China

[2] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China

来源：

TETRAHEDRON | 2008年 / 64卷 / 49期

基金：

中国国家自然科学基金;

关键词：

Multicomponent; One-pot; 3-Substituted isoindolinones; C-C bond formation;

D O I：

10.1016/j.tet.2008.09.092

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new three-component reaction among o-phthalaldehyde, N-alkyl/aryl Substituted urea, and an aromatic aldehyde has been developed at ambient condition, and a class of isoindolinones with novel C-3 Substitution were conveniently synthesized. The general diastereomeric excess is high as over 99% of the products indicated the excellent stereoselectivity posed in this multicomponent reaction. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：11115 / 11123

页数：9

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