Laboratory, clinical and therapeutic aspects of acquired hemophilia A

被引:52
|
作者
Franchini, Massimo [1 ]
Targher, Giovanni [2 ]
Montagnana, Martina [3 ]
Lippi, Giuseppe [3 ]
机构
[1] Azienda Osped Verona, Ctr Emofilia, Serv Immunoematol & Trasfus, Verona, Italy
[2] Univ Verona, Sez Endocrinol & Malattie Metab, Dipartimento Sci Biomed & Chirurg, I-37100 Verona, Italy
[3] Univ Verona, Ist Chim & Microscopia Clin, Dipartimento Sci Morfol Biomed, I-37100 Verona, Italy
关键词
acquired hemophilia; factor VIII; inhibitor; hemorrhage;
D O I
10.1016/j.cca.2008.05.003
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Acquired hemophilia A is a rare bleeding diathesis caused by autoantibodies directed against clotting factor VIII and associated with an increased morbidity and mortality. This disease occurs most commonly in the elderly, and although it may be associated with a variety of underlying pathological conditions, up to 50% of reported cases remain idiopathic. In this review, we report the present knowledge on the most important laboratory, diagnostic and clinical aspects of acquired hemophilia A. Moreover, we focus on the most recent advances in the treatment of this disorder, which is primarily aimed to control bleeding episodes and to eradicate the autoantibody production. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:14 / 18
页数:5
相关论文
共 50 条
  • [31] Acquired hemophilia
    Huisman, P
    Eggink, HD
    van Zoelen, BJ
    Nortier, JWR
    NETHERLANDS JOURNAL OF MEDICINE, 2000, 56 (06): : 229 - 231
  • [32] ACQUIRED HEMOPHILIA
    DURANSUAREZ, JR
    PIGRAUSERRALLACH, C
    BOSCHGIL, JA
    TRIGINERBOIXEDA, J
    LANCET, 1981, 1 (8222): : 723 - 723
  • [33] ACQUIRED HEMOPHILIA
    BOUVRY, P
    RECLOUX, P
    HAEMATOLOGICA, 1994, 79 (06) : 550 - 556
  • [34] Acquired Hemophilia A
    Webert, Kathryn E.
    SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2012, 38 (07): : 735 - 741
  • [35] Acquired hemophilia
    Ros, JO
    Roca, CA
    MEDICINA CLINICA, 2002, 119 (20): : 773 - 775
  • [36] ACQUIRED HEMOPHILIA A
    Franchini, Massimo
    Lippi, Giuseppe
    ADVANCES IN CLINICAL CHEMISTRY, VOL 54, 2011, 54 : 71 - 80
  • [37] Acquired Hemophilia
    Kimura, Kenji
    Kuriyama, Akira
    Kuninaga, Naoki
    Sasaki, Akira
    INTERNAL MEDICINE, 2015, 54 (07) : 865 - 865
  • [38] Acquired Hemophilia A
    Pai, Menaka
    HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2021, 35 (06) : 1131 - 1142
  • [39] Acquired hemophilia A
    Franchini, Massimo
    HEMATOLOGY, 2006, 11 (02) : 119 - 125
  • [40] ACQUIRED HEMOPHILIA
    不详
    LABORATORY MEDICINE, 1991, 22 (02) : 89 - 90