Laboratory, clinical and therapeutic aspects of acquired hemophilia A

被引：52

作者：

Franchini, Massimo ^{[1
]}

Targher, Giovanni ^{[2
]}

Montagnana, Martina ^{[3
]}

Lippi, Giuseppe ^{[3
]}

机构：

[1] Azienda Osped Verona, Ctr Emofilia, Serv Immunoematol & Trasfus, Verona, Italy

[2] Univ Verona, Sez Endocrinol & Malattie Metab, Dipartimento Sci Biomed & Chirurg, I-37100 Verona, Italy

[3] Univ Verona, Ist Chim & Microscopia Clin, Dipartimento Sci Morfol Biomed, I-37100 Verona, Italy

来源：

CLINICA CHIMICA ACTA | 2008年 / 395卷 / 1-2期

关键词：

acquired hemophilia; factor VIII; inhibitor; hemorrhage;

D O I：

10.1016/j.cca.2008.05.003

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Acquired hemophilia A is a rare bleeding diathesis caused by autoantibodies directed against clotting factor VIII and associated with an increased morbidity and mortality. This disease occurs most commonly in the elderly, and although it may be associated with a variety of underlying pathological conditions, up to 50% of reported cases remain idiopathic. In this review, we report the present knowledge on the most important laboratory, diagnostic and clinical aspects of acquired hemophilia A. Moreover, we focus on the most recent advances in the treatment of this disorder, which is primarily aimed to control bleeding episodes and to eradicate the autoantibody production. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：14 / 18

页数：5

共 50 条

[11] ACQUIRED HEMOPHILIA: FROM DIAGNOSIS TO NOVEL THERAPEUTIC ADVANCES
Castaman, G.
HAEMATOLOGICA, 2015, 100 : 189 - 191
[12] Acquired Hemophilia A in Peripartum Period: Diagnostic and Therapeutic Dilemma
Bin Waqar, Syed Hamza
Khoury, Leen
Hussain, Ather
McFarlane, Isabel M.
CUREUS JOURNAL OF MEDICAL SCIENCE, 2021, 13 (08)
[13] THERAPEUTIC AND PATHOGENETIC ASPECTS OF ARTICULAR AFFECTIONS IN HEMOPHILIA
KARGIN, VD
NAZAROVA, NS
EGOROVA, LV
GEMATOLOGIYA I TRANSFUZIOLOGIYA, 1993, 38 (09): : 22 - 24
[14] Unravelling Acquired Hemophilia A in an Ambiguous Clinical Picture
Ayoobkhan, Fathima Shehnaz
Padmanabhan, Dakshin S.
Mahayni, Rula
Riaz, Sara
Krishnamoorthy, Geetha
CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (09)
[15] Churg-Strauss syndrome: update on clinical, laboratory and therapeutic aspects
Keogh, Karina A.
Specks, Ulrich
SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, 2006, 23 (01) : 3 - 12
[16] Diagnosis and management of acquired hemophilia A: clinical experience
Svorcova, V.
Salaj, P.
Fetterova, V.
Hrachovinova, I. .
Cetkovsky, P. .
HAEMOPHILIA, 2008, 14 : 3 - 3
[17] The economic and clinical burden of acquired hemophilia A (AHA)
Lin, Vincent W.
Novack, Aaron
Testa, Deborah
Epstein, Joshua
HAEMOPHILIA, 2014, 20 : 1 - 1
[18] CLINICAL ASPECTS OF HEMOPHILIA AND VONWILLEBRANDS DISEASE
CIAVARELLA, D
COUNTS, RB
AMERICAN JOURNAL OF MEDICAL TECHNOLOGY, 1983, 49 (12): : 850 - 854
[19] NEW CLINICAL ASPECTS OF HEMOPHILIA TREATMENT
MEILI, EO
SCHWEIZERISCHE MEDIZINISCHE WOCHENSCHRIFT, 1989, 119 (39) : 1332 - 1341
[20] ACQUIRED HEMOPHILIA AND LABORATORY DIAGNOSTIC ISSUES: A CASE-REPORT
Goncalves, D. C.
Pinto, B. L.
Monteiro, C.
Goncalves, L. R.
Carvalho, M.
Koch, C.
HAEMOPHILIA, 2020, 26 : 31 - 31

← 1 2 3 4 5 →