Lipase-mediated resolution of cis-1-amino-2-indanol, the key component of the HIV protease inhibitor indinavir

被引：13
|
作者：
Anilkumar, AT [1 ]
Goto, K [1 ]
Takahashi, T [1 ]
Ishizaki, K [1 ]
Kaga, H [1 ]
机构：
[1] Hokkaido Natl Ind Res Inst, Sapporo, Hokkaido 0628517, Japan
来源：
TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 13期
关键词：
D O I：
10.1016/S0957-4166(99)00260-8
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The efficient and direct resolution of cis-1-amino-2-indanol using Candida antarctica lipase B catalyzing the alcoholysis of its N,O-diacetyl derivative is reported. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2501 / 2503
页数：3
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