Synthesis of pyrrole phosphonate esters: Emphasis on pyrrole NH acids and dialkylacetylenic esters substitution

被引：0
|
作者：
Maghsoodlou, Malek Taher [1 ]
Rostami, Charati Faramarz [2 ]
Habibi, Khorassani Sayed Mostafa [1 ]
Khosroshahrodi, Maryam [1 ]
Makha, Mohamed [3 ]
机构：
[1] Univ Sistan & Baluchestan, Dept Chem, Zahedan, Iran
[2] Gorgan Univ Agr Sci & Nat Resources, High Educ Ctr, Gonbad, Iran
[3] Univ Western Australia, Sch Biomed Biomol & Chem Sci, Perth, WA 6009, Australia
来源：
IRANIAN JOURNAL OF CHEMISTRY & CHEMICAL ENGINEERING-INTERNATIONAL ENGLISH EDITION | 2008年 / 27卷 / 01期
关键词：
organophosphorus compounds; acetylenic diesters; substituted pyrrole; phosphonate esters; diastereoisomers;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Reaction of dialkyl acetylenedicarboxylates la-c and pyrrole derivatives 2a-e in the presence of triphenylphosphite (TPP) was investigated and the effect of the pyrrole substitution was established. Diastereoselectivity is observed with pyrroles, 2a,b, yielding phosphonate ester derivatives 3a-f and 4, and their relative configuration is determined by H-1/C-13 and (31)p NMR and confirmed by single X-ray diffraction. Similar reactions with higher degree of substitution of the pyrrole, 2c,e showed no diastereoselectivity.
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页码：105 / 113
页数：9
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