Synthesis of pyrrole phosphonate esters: Emphasis on pyrrole NH acids and dialkylacetylenic esters substitution

被引：0

作者：

Maghsoodlou, Malek Taher ^{[1
]}

Rostami, Charati Faramarz ^{[2
]}

Habibi, Khorassani Sayed Mostafa ^{[1
]}

Khosroshahrodi, Maryam ^{[1
]}

Makha, Mohamed ^{[3
]}

机构：

[1] Univ Sistan & Baluchestan, Dept Chem, Zahedan, Iran

[2] Gorgan Univ Agr Sci & Nat Resources, High Educ Ctr, Gonbad, Iran

[3] Univ Western Australia, Sch Biomed Biomol & Chem Sci, Perth, WA 6009, Australia

来源：

IRANIAN JOURNAL OF CHEMISTRY & CHEMICAL ENGINEERING-INTERNATIONAL ENGLISH EDITION | 2008年 / 27卷 / 01期

关键词：

organophosphorus compounds; acetylenic diesters; substituted pyrrole; phosphonate esters; diastereoisomers;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reaction of dialkyl acetylenedicarboxylates la-c and pyrrole derivatives 2a-e in the presence of triphenylphosphite (TPP) was investigated and the effect of the pyrrole substitution was established. Diastereoselectivity is observed with pyrroles, 2a,b, yielding phosphonate ester derivatives 3a-f and 4, and their relative configuration is determined by H-1/C-13 and (31)p NMR and confirmed by single X-ray diffraction. Similar reactions with higher degree of substitution of the pyrrole, 2c,e showed no diastereoselectivity.

引用

页码：105 / 113

页数：9

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