We present a bilayer lift-off process without spin coating step, based on evaporated negative ebeam resist QSR-5. This technique is appropriated to process small samples of a few millimetres in size. Evaporated amorphous silicon was used to create the undercut. Patterns were defined by electron beam lithography thanks to the high resolution QSR-5 resist. We optimized the undercut of the a-Si layer using a high density plasma etching system with different recipes to allow submicron lines lift-off. Lift-off with no edge bead effect was performed using this technique. Finally, the process was applied to demonstrate the fabrication of Metal/Semiconductor/Metal (MSM) photodetector on a millimetre scale substrate. Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved.