Synthesis and biological activity of some novel isoxazoles derived from benzosuberones

被引：0
|
作者：
Rupavani, Bandapally [1 ]
Venkateswarlu, Peesapati [1 ]
机构：
[1] Palamuru Univ, Adarsh Degree & PG Coll, Dept Chem, Mahabubnagar 509001, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2019年 / 58卷 / 04期
关键词：
2,3-Dimethy1-6,7,8,9-tetrahydrobenzocyclohepten-5-one; isoxazoles; anticancer activity;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A class of novel isoxazoles 3a-h derived from 2, 3-dimethyl-6-arylidene-6,7,8,9-tetrahydro-5H- benzo[a]cyclohepten5-ones 2a-h have been reported and characterized by spectral analysis. The compounds have been assayed for their potential anticancer activity on human cancer cell lines. Compounds 3a, 3c show moderate anti cancer activity towards prostate cancer and 3a, 3c, 3f show mild activity towards breast cancer.
引用
收藏
页码：511 / 515
页数：5
相关论文
共 50 条
  • [31] Synthesis, Characterization and Biological Activity of Some Novel Formazan Derivatives
    Babu, A. Narendra
    Nadendla, Rama Rao
    ASIAN JOURNAL OF CHEMISTRY, 2011, 23 (03) : 1349 - 1352
  • [32] Synthesis and Biological Activity of Piperidinothiosemicarbazones Derived from Aminoazinecarbonitriles
    Ziembicka, Dagmara
    Gobis, Katarzyna
    Szczesio, Malgorzata
    Augustynowicz-Kopec, Ewa
    Glogowska, Agnieszka
    Korona-Glowniak, Izabela
    Bojanowski, Krzysztof
    PHARMACEUTICALS, 2023, 16 (09)
  • [33] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME SCHIFF-BASES DERIVED FROM THIAZOLES AND BENZOTHIAZOLES
    DASH, B
    PATRA, M
    PRAHARAJ, S
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1980, 19 (10): : 894 - 897
  • [34] Synthesis, Antiinflammatory and Antibacterial Activity of Novel Indolyl-isoxazoles
    Panda, S. S.
    Chowdary, P. V. R.
    Jayashree, B. S.
    INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 71 (06) : 684 - U5
  • [35] Synthesis, spectral features and biological activity of some novel hetarylazo dyes derived from 6-amino-1,3-dimethyluracil
    Yousefi, Hessamoddin
    Yahyazadeh, Asieh
    Yazdanbakhsh, Mohammad Reza
    Rassa, Mehdi
    Moradi-e-Rufchahi, Enayat O'llah
    JOURNAL OF MOLECULAR STRUCTURE, 2012, 1015 : 27 - 32
  • [36] SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME PYRAZOLINES DERIVED FROM BENZOFURAN
    Basawaraj, Raga
    Goled, Shashikanth
    Sangapure, S. S.
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2009, 19 (02) : 201 - 202
  • [37] Synthesis of novel phytol-derived γ-butyrolactones and evaluation of their biological activity
    Anna Gliszczyńska
    Katarzyna Dancewicz
    Beata Gabryś
    Marta Świtalska
    Joanna Wietrzyk
    Gabriela Maciejewska
    Scientific Reports, 11
  • [38] Synthesis of novel phytol-derived γ-butyrolactones and evaluation of their biological activity
    Gliszczynska, Anna
    Dancewicz, Katarzyna
    Gabrys, Beata
    Switalska, Marta
    Wietrzyk, Joanna
    Maciejewska, Gabriela
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [39] A novel synthesis of isoxazoles derivatives
    Wang, JF
    Peng, YG
    Du, BS
    CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2002, 23 (06): : 1097 - 1099
  • [40] SYNTHESIS OF SOME NEW QUINOLINO PYRIMIDINES AND ISOXAZOLES AND EVALUATION OF THEIR ANTIMICROBIAL ACTIVITY
    Mistry, B. D.
    Desai, K. R.
    Patel, N. I.
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2011, 20 (03) : 261 - 264
12345