Synthesis and biological activity of some novel isoxazoles derived from benzosuberones

被引：0
|
作者：
Rupavani, Bandapally [1 ]
Venkateswarlu, Peesapati [1 ]
机构：
[1] Palamuru Univ, Adarsh Degree & PG Coll, Dept Chem, Mahabubnagar 509001, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2019年 / 58卷 / 04期
关键词：
2,3-Dimethy1-6,7,8,9-tetrahydrobenzocyclohepten-5-one; isoxazoles; anticancer activity;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A class of novel isoxazoles 3a-h derived from 2, 3-dimethyl-6-arylidene-6,7,8,9-tetrahydro-5H- benzo[a]cyclohepten5-ones 2a-h have been reported and characterized by spectral analysis. The compounds have been assayed for their potential anticancer activity on human cancer cell lines. Compounds 3a, 3c show moderate anti cancer activity towards prostate cancer and 3a, 3c, 3f show mild activity towards breast cancer.
引用
收藏
页码：511 / 515
页数：5
相关论文
共 50 条
  • [21] Novel triazole alcohol antifungals derived from fluconazole: design, synthesis, and biological activity
    Seyedeh Mahdieh Hashemi
    Hamid Badali
    Mohammad Ali Faramarzi
    Nasrin Samadi
    Mohammad Hosein Afsarian
    Hamid Irannejad
    Saeed Emami
    Molecular Diversity, 2015, 19 : 15 - 27
  • [22] Novel triazole alcohol antifungals derived from fluconazole: design, synthesis, and biological activity
    Hashemi, Seyedeh Mahdieh
    Badali, Hamid
    Faramarzi, Mohammad Ali
    Samadi, Nasrin
    Afsarian, Mohammad Hosein
    Irannejad, Hamid
    Emami, Saeed
    MOLECULAR DIVERSITY, 2015, 19 (01) : 15 - 27
  • [23] SYNTHESIS, CRYSTAL STRUCTURE, AND BIOLOGICAL ACTIVITY OF NOVEL CURCUMIN ANALOGUES DERIVED FROM CINNAMALDEHYDE
    B. Lu
    S. H. Ren
    Y. Lin
    W. Q. Liu
    P. N. Wan
    H. F. Cui
    Journal of Structural Chemistry, 2021, 62 : 1123 - 1130
  • [24] Synthesis and Biological Activity of Novel α-Conotoxins Derived from Endemic Polynesian Cone Snails
    Souf, Yazid Mohamed
    Lokaj, Gonxhe
    Kuruva, Veeresh
    Saed, Yakop
    Raviglione, Delphine
    Brik, Ashraf
    Nicke, Annette
    Inguimbert, Nicolas
    Dutertre, Sebastien
    MARINE DRUGS, 2023, 21 (06)
  • [25] Synthesis and biological evaluation of some novel isoxazoles and cyanopyridines, a new class of potential anti-tubercular agents
    Doshi, R
    Kagthara, P
    Parekh, H
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1999, 38 (03): : 348 - 352
  • [26] Synthesis, characterization and biological activity of some novel benzimidazole derivatives
    Jafar, Ahamed A.
    Vijayakumar, Kaliapillai N.
    Venkatraman, Bathey R.
    Venkatesh, Govindaraj
    ORBITAL-THE ELECTRONIC JOURNAL OF CHEMISTRY, 2009, 1 (04): : 306 - 309
  • [27] Synthesis and evaluation of biological activity of some novel carbazole derivatives
    Kumar, Umesh
    Gupta, Sujeet Kumar
    Yogi, Bhumika
    Kumar, Surendra
    INDIAN JOURNAL OF CHEMISTRY, 2023, 62 (01): : 60 - 64
  • [28] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME NOVEL ANALOGS OF THYMIDINE
    CHENG, YC
    NEENAN, JP
    GOZ, B
    WARD, DC
    PRUSOFF, WH
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1975, 255 (AUG8) : 332 - 341
  • [29] Synthesis of Some Novel Quinazolinone Derivatives with Anticipated Biological Activity
    Marzouk, Magda I.
    Shaker, Soheir A.
    Farghaly, Thoraya A.
    El-Hashash, Maher A.
    Hussein, Shadia M.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2017, 54 (06) : 3331 - 3341
  • [30] SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NOVEL SUBSTITUTED QUINAZOLINE DERIVATIVES
    Srivastav, Maneesh Kumar
    Rajeeva, B.
    Salahuddin, Md
    Srinivasulu, N.
    Kumar, S. M. Shanta
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2014, 24 (02) : 115 - 118
12345