Palladacycle-Catalyzed Reaction of Bicyclic Alkenes with Terminal Ynones: Regiospecific Synthesis of Polysubstituted Furans

被引：44

作者：

Ge, Guang-Cun ^{[1
]}

Mo, Dong-Liang ^{[1
]}

Ding, Chang-Hua ^{[1
]}

Dai, Li-Xin ^{[1
]}

Hou, Xue-Long ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai Hong Kong Joint Lab Chem Synth, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 22期

基金：

中国国家自然科学基金;

关键词：

OXABICYCLIC ALKENES; REGIOSELECTIVE SYNTHESIS; TETRASUBSTITUTED FURANS; SUBSTITUTED FURANS; 2+2 CYCLOADDITION; PALLADIUM; ALKYNES; KETONES; DIMERIZATION; DERIVATIVES;

D O I：

10.1021/ol302586m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new synthetic strategy to access polysubstituted furans regiospecifically has been developed using simple bicyclic alkenes and terminal ynones as starting materials with palladacycles as unique active catalysts. A rational mechanism has also been proposed. This reaction features mild reaction conditions, easily available starting materials and palladacycle catalysts, a wide substrate scope, and high regiospecificity.

引用

页码：5756 / 5759

页数：4

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