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Gold-Catalyzed Cascade Reaction of β-(2-Aminophenyl)-α,β-ynones with Ynamides: A Sequential Route to Polysubstituted 2-Aminoquinolines
被引:52
|作者:
Rode, Navnath D.
[1
]
Arcadi, Antonio
[1
]
Di Nicola, Antonella
[1
]
Marinelli, Fabio
[1
]
Michelet, Veronique
[2
]
机构:
[1] Univ Aquila, Dipartimento Sci Fis & Chim, Via Vetoio, I-67010 Coppito, AQ, Italy
[2] Univ Cote dAzur, Inst Chim Nice, UMR CNRS 7272, Fac Sci, Parc Valrose, F-06100 Nice, France
关键词:
DOMINO HYDROARYLATION/CYCLOISOMERIZATION REACTIONS;
SILYL ENOL ETHERS;
QUINOLINE;
ACCESS;
CYCLIZATIONS;
POTENT;
AMINATION;
EFFICIENT;
ALKALOIDS;
D O I:
10.1021/acs.orglett.8b01928
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
A novel, efficient, and mild synthetic route for the preparation of 2-aminoquinolines via a gold-catalyzed cascade reaction of beta-(2-aminophenyl)-alpha,beta-ynones with ynamides has been developed. This process tolerates a wide range of functionalities such as halogen, alkyl, aryl, and heteroaryl groups, leading to original heterocycles in fair to very good yields.
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页码:5103 / 5106
页数:4
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