Gold-Catalyzed Cascade Reaction of β-(2-Aminophenyl)-α,β-ynones with Ynamides: A Sequential Route to Polysubstituted 2-Aminoquinolines

被引：52
|
作者：
Rode, Navnath D. [1 ]
Arcadi, Antonio [1 ]
Di Nicola, Antonella [1 ]
Marinelli, Fabio [1 ]
Michelet, Veronique [2 ]
机构：
[1] Univ Aquila, Dipartimento Sci Fis & Chim, Via Vetoio, I-67010 Coppito, AQ, Italy
[2] Univ Cote dAzur, Inst Chim Nice, UMR CNRS 7272, Fac Sci, Parc Valrose, F-06100 Nice, France
来源：
ORGANIC LETTERS | 2018年 / 20卷 / 17期
关键词：
DOMINO HYDROARYLATION/CYCLOISOMERIZATION REACTIONS; SILYL ENOL ETHERS; QUINOLINE; ACCESS; CYCLIZATIONS; POTENT; AMINATION; EFFICIENT; ALKALOIDS;
D O I：
10.1021/acs.orglett.8b01928
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel, efficient, and mild synthetic route for the preparation of 2-aminoquinolines via a gold-catalyzed cascade reaction of beta-(2-aminophenyl)-alpha,beta-ynones with ynamides has been developed. This process tolerates a wide range of functionalities such as halogen, alkyl, aryl, and heteroaryl groups, leading to original heterocycles in fair to very good yields.
引用
收藏
页码：5103 / 5106
页数：4
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