Reaction of β-(2-aminophenyl)-α,β-Ynones with Tosyl Isocyanate: Experimental and Computational Investigations

被引：10

作者：

Rode, Navnath D. ^{[1
]}

Aschi, Massimiliano ^{[1
]}

Chiarini, Marco ^{[2
]}

Del Vecchio, Luana ^{[1
]}

Marinelli, Fabio ^{[1
]}

Arcadi, Antonio ^{[1
]}

机构：

[1] Univ Aquila, Dipartimento Sci Fis & Chim, Via Vetoio, I-67010 Coppito, AQ, Italy

[2] Univ Teramo, Fac Biosci & Tecnol Agroalimentari & Ambientali, Via Balzarini 1, I-64100 Teramo, TE, Italy

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2018年 / 360卷 / 19期

关键词：

beta-(2-Aminophenyl); alpha; beta-ynones; 2-Aroyl-1H-indole-3; carboxamides; Tosyl isocyanate; Aminocarboxyamidation; DFT; CATALYZED CYCLIZATION; HETEROCYCLIZATION; DENSITY;

D O I：

10.1002/adsc.201800733

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A practical metal-free approach to the synthesis of 2-aroyl-N-tosyl-1H-indole-3 carboxamides through an unprecedented sequential 5-endo-dig cycloamination /carboxamidation reaction of beta-(2-aminophenyl)-alpha,beta-ynones with the tosyl isocyanate is described. A computational model gives a plausible rationale for the unexpected results.

引用

页码：3672 / 3676

页数：5

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