Suzuki-type cross-coupling reaction of 3-iodoindazoles with aryl boronic acids: a general and flexible route to 3-arylindazoles

被引：87
|
作者：
Collot, V
Dallemagne, P
Bovy, PR
Rault, S
机构：
[1] Univ Caen, UFR Sci Pharmaceut, Ctr Etud & Rech Medicament Normandie, F-14032 Caen, France
[2] Synthelabo Rech, F-92500 Rueil Malmaison, France
来源：
TETRAHEDRON | 1999年 / 55卷 / 22期
关键词：
D O I：
10.1016/S0040-4020(99)00324-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This paper describes a Suzuki Type cross coupling reaction of 3-iodoindazoles with aryl and heteroaryl boronic acids as a general route to 3-arylindazoles. The coupling reaction is illustrated by the preparation of new aryl- or heteroarylindazoles 7. Scope and limitation of the method are outlined. The coupling reaction works best on a 1-substituted indazole nucleus. The usefulness of the reaction is illustrated by a short practical synthesis of YC-1, a pharmacological agent potentialy useful for the treatment of cardiovascular diseases or erectile dysfunction. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：6917 / 6922
页数：6
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