Kinetics of the Solid-State Cyclization of Glycylglycine Dipeptide

被引：4
|
作者：
Larionov, R. A. [1 ]
Akhmetshin, Sh. R. [1 ]
Gerasimov, A. V. [1 ]
Morozova, A. S. [2 ]
Ziganshina, S. A. [2 ]
Khayarov, Kh. R. [1 ]
Gorbatchuk, V. V. [1 ]
Ziganshin, M. A. [1 ]
机构：
[1] Kazan Volga Reg Fed Univ, Butlerov Inst Chem, Kazan 420008, Russia
[2] Russian Acad Sci, Kazan Res Ctr, Zavoisky Phys Tech Inst, Kazan 420029, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 58卷 / 08期
关键词：
glycylglycine; 2; 5-diketopiperazine; solid-state cyclization; reaction kinetics; self-assembly of dipeptides; DIKETOPIPERAZINES; BACTERIA; GLYCINE; SPONGE;
D O I：
10.1134/S1070428022080024
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The cyclization of glycylglycine dipeptide in the solid state under heating to form 2,5-diketopiperazine was studied, and its temperature range was determined. The possibility of using of the approaches of isoconversion kinetics to determine the kinetic parameters of the reaction, including the activation energy and the Arrhenius constant, is demonstrated. The kinetics of the solid-state cyclization of glycylglycine is best fit by the rate equation for an autocatalytic reaction. The self-assembly of glycylglycine and cyclo(glycylglycyl) from a solution in hexafluoroisopropanol on the surface of highly oriented pyrolytic graphite was studied by atomic force microscopy.
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页码：1076 / 1083
页数：8
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