The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse

被引:1
|
作者
Canbay, A
Feldstein, A
Baskin-Bey, E
Bronk, SF
Gerken, G
Gores, GJ
机构
[1] Mayo Clin & Mayo Fdn, Mayo Med Sch, Ctr Basic Res Digest Dis, Rochester, MN 55905 USA
[2] Univ Hosp Essen, Dept Gastroenterol & Hepatol, Essen, Germany
关键词
D O I
10.1016/S0168-8278(04)90022-0
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
22
引用
收藏
页码:9 / 9
页数:1
相关论文
共 50 条
  • [21] IDN-6556, the first anti-apoptotic caspase inhibitor in clinical trials: Tissue distribution and pharmacokinetics.
    Chen, LS
    Hoglen, NC
    Fisher, CD
    Valentino, KL
    Contreras, PC
    HEPATOLOGY, 2003, 38 (04) : 580A - 581A
  • [22] Overexpression of Mcl-1 Attenuates Liver Injury and Fibrosis in the Bile Duct-Ligated Mouse
    Kahraman, Alisan
    Mott, Justin L.
    Bronk, Steven F.
    Werneburg, Nathan W.
    Barreyro, Fernando J.
    Guicciardi, Maria E.
    Akazawa, Yuko
    Braley, Karen
    Craig, Ruth W.
    Gores, Gregory J.
    DIGESTIVE DISEASES AND SCIENCES, 2009, 54 (09) : 1908 - 1917
  • [23] The caspase inhibitor IDN-6556 (PF3491390) improves marginal mass engraftment after islet transplantation in mice
    McCall, Michael
    Toso, Christian
    Emamaullee, Juliet
    Pawlick, Rena
    Edgar, Ryan
    Davis, Joy
    Maciver, Allison
    Kin, Tatsuya
    Arch, Robert
    Shapiro, A. M. James
    SURGERY, 2011, 150 (01) : 48 - 55
  • [24] Sirolimus Attenuates Hepatocellular Injury and Fibrosis in Bile Duct Ligated Rats and Human Hepatic Stellate Cells.
    Chen, Y.
    Luo, W.
    Ma, Y.
    He, X.
    Guo, Z.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2014, 14 : 281 - 281
  • [25] Sirolimus Attenuates Hepatocellular Injury and Fibrosis in Bile Duct Ligated Rats and Human Hepatic Stellate Cells.
    Chen, Y.
    Luo, W.
    Ma, Y.
    He, X.
    Guo, Z.
    TRANSPLANTATION, 2014, 98 : 281 - 281
  • [26] Rapamycin Attenuates Hepatocellular Injury and Fibrosis in Bile Duct-Ligated Rats and Human Hepatic Stellate Cells
    Chen, Yinghua
    Luo, Wenhui
    Ma, Yi
    He, Xiaoshun
    LIVER TRANSPLANTATION, 2014, 20 : S233 - S233
  • [27] Cts-1027, a broad-spectrum matrix metalloprotease inhibitor, attenuates liver injury and fibrosis in the bile duct-ligated mouse
    Kahraman, Alisan
    Bronk, Steven F.
    Cazanave, Sophie
    Werneburg, Nathan W.
    Mott, Justin L.
    Contreras, Patricia
    Gores, Gregory J.
    GASTROENTEROLOGY, 2008, 134 (04) : A767 - A767
  • [28] Emodin Attenuates Hepatocellular Injury and Fibrosis in Bile Duct-Ligated Mice.
    Chen, Y.
    Luo, W.
    Ma, Y.
    He, X.
    Guo, Z.
    TRANSPLANTATION, 2014, 98 : 281 - 281
  • [29] Emodin Attenuates Hepatocellular Injury and Fibrosis in Bile Duct-Ligated Mice.
    Chen, Y.
    Luo, W.
    Ma, Y.
    He, X.
    Guo, Z.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2014, 14 : 281 - 281
  • [30] Gardenia jasminoides attenuates hepatocellular injury and fibrosis in bile duct-ligated rats and human hepatic stellate cells
    Ying-Hua Chen
    Tian Lan
    Jing Li
    Chun-Hui Qiu
    Teng Wu
    Hong-Ju Gou
    Min-Qiang Lu
    World Journal of Gastroenterology, 2012, 18 (48) : 7158 - 7165