IDN-6556, the first anti-apoptotic caspase inhibitor in clinical trials: Tissue distribution and pharmacokinetics.

被引:0
|
作者
Chen, LS [1 ]
Hoglen, NC [1 ]
Fisher, CD [1 ]
Valentino, KL [1 ]
Contreras, PC [1 ]
机构
[1] Idun Pharmaceut Inc, San Diego, CA USA
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
874
引用
收藏
页码:580A / 581A
页数:2
相关论文
共 9 条
  • [1] First clinical trial of IDN-6556: First anti-apoptotic caspase inhibitor improves liver function
    Valentino, K
    Gutierrez, M
    Sanchez, R
    Pockros, P
    Winship, MJ
    Shapiro, D
    GASTROENTEROLOGY, 2002, 122 (04) : A622 - A622
  • [2] First clinical trial of a novel caspase inhibitor: anti-apoptotic caspase inhibitor, IDN-6556, improves liver enzymes
    Valentino, KL
    Gutierrez, M
    Sanchez, R
    Winship, MJ
    Shapiro, DA
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2003, 41 (10) : 441 - 449
  • [3] IDN-6556, the first anti-apoptotic caspase inhibitor: Preclinical efficacy and safety.
    Hoglen, NC
    Fisher, CD
    Hirakawa, BP
    Valentino, KL
    Shapiro, DA
    Contreras, PC
    HEPATOLOGY, 2003, 38 (04) : 579A - 579A
  • [4] Oral IDN-6556, an anti-apoptotic caspase inhibitor, lowers aminotransferases in HCV patients
    Schiff, ER
    Pockros, P
    Shiffman, ML
    McHutchison, J
    Gish, R
    Afdhal, NH
    Makhviladze, M
    Huyghe, M
    Hecht, D
    Oltersdorf, T
    Shapiro, DA
    GASTROENTEROLOGY, 2004, 126 (04) : A668 - A668
  • [5] Oral IDN-6556, an anti-apoptotic caspase inhibitor, lowers aminotransferases in HCV patients
    Schiff, ER
    Pockros, P
    Schiffman, ML
    McHutchison, J
    Gish, R
    Afdhal, NH
    Makhviladze, M
    Oltersdorf, T
    Shapiro, DA
    JOURNAL OF HEPATOLOGY, 2004, 40 : 24 - 24
  • [6] Clinical trial of the pan-caspase inhibitor, IDN-6556, in human liver preservation injury
    Baskin-Bey, E. S.
    Washburn, K.
    Feng, S.
    Oltersdorf, T.
    Shapiro, D.
    Huyghe, MiRa
    Burgart, L.
    Garrity-Park, M.
    van Vilsteren, F. G. I.
    Oliver, L. K.
    Rosen, C. B.
    Gores, G. J.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2007, 7 (01) : 218 - 225
  • [7] Letter to the Editor: Is Emricasan (IDN-6556), an Oral Pan-Caspase Inhibitor, Ready for Controlled Trials?
    Khurana, Sandeep
    Khara, Harshit S.
    HEPATOLOGY, 2019, 70 (03) : 1078 - 1079
  • [8] Letter to the Editor: Is Emricasan (IDN-6556), an Oral Pan-Caspase Inhibitor, Ready for Controlled Trials? Reply
    Hagerty, David
    Garcia-Tsao, Guadalupe
    Bosch, Jaime
    HEPATOLOGY, 2019, 70 (03) : 1079 - 1080
  • [9] Discovery of potent, anti-apoptotic caspase inhibitors and development of the clinical candidate ion 6556.
    Spada, AP
    Karanewsky, D
    Ternansky, R
    Ching, B
    Ullman, B
    Linton, S
    Robinson, E
    Meduna, S
    Jahangini, K
    Wu, J
    Contreras, P
    Hayes, T
    Winship, J
    Tomaselli, K
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 224 : U81 - U81