Synthesis, structure, DNA and protein binding studies, and cytotoxic activity of nickel(II) complexes containing 3,3-dialkyl/aryl-1-(2,4-dichlorobenzoyl)thiourea ligands

被引：46

作者：

Selvakumaran, N. ^{[1
]}

Bhuvanesh, N. S. P. ^{[2
]}

Endo, A. ^{[3
]}

Karvembu, R. ^{[1
]}

机构：

[1] Natl Inst Technol, Dept Chem, Tiruchirappalli 620015, Tamil Nadu, India

[2] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA

[3] Sophia Univ, Dept Mat & Life Sci, Chiyoda Ku, Tokyo 1028554, Japan

来源：

POLYHEDRON | 2014年 / 75卷

关键词：

Acylthiourea; Ni(II) complex; DNA binding; BSA interaction; Cytotoxicity; LIQUID-MEMBRANE TRANSPORT; CRYSTAL-STRUCTURE; BIOLOGICAL-ACTIVITY; ZINC(II) COMPLEXES; IN-VITRO; RUTHENIUM(II) COMPLEXES; ANTITUMOR-ACTIVITY; COBALT COMPLEXES; METAL; PHOTOCLEAVAGE;

D O I：

10.1016/j.poly.2014.03.010

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new series of nickel(II) complexes of the type [Ni(L)(2)] (1-6) has been synthesized by using the 3,3-dialkyliaryl-1-(2,4-dichlorobenzoyl)thiourea ligands, and characterized by analytical and spectral (NMR, FT-IR and UV-Vis) techniques. The structures of the ligands (HL1, HL2 and HL3) and complexes (2 and 5) have been confirmed by single crystal X-ray diffraction studies. The interaction of the nickel(II) complexes (2-5) with calf thymus (CT) DNA and bovine serum albumin (BSA) protein was investigated using UV-Vis and fluorescence spectroscopic methods. Absorption and emission spectral studies indicate that complex 2 interacts with CT DNA and BSA protein more strongly than the other complexes (3, 4 and 5). Complexes 2 and 5 exhibited good cytotoxicity against A549 and HT29 cell lines at 50 mu M concentration. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：95 / 109

页数：15

共 39 条

[31] Mn(II) complexes of 1-(4-methoxybenzoyl)-4-phenyl-3-thiosemicarbazide containing o-phenanthroline and 2,2-bipyridine as co-ligands: Synthesis, crystal structure, spectral characterization, photoluminescence and electrochemical studies
Gautam, Ram Nayan
Tiwari, Ananya
Gupta, Seema
Bharty, M. K.
Ganesan, Vellaichamy
Kumar, Sundeep
Bharati, P.
Butcher, R. J.
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[32] STUDIES OF PENDANT ARM MACROCYCLIC LIGANDS .6. SYNTHESIS OF 2 PENTA-AZA MACROCYCLIC LIGANDS CONTAINING SINGLE PENDANT COORDINATING 2-PYRIDYLMETHYL AND 1-PYRAZOLYLMETHYL ARMS, AND CHARACTERIZATION OF THEIR NICKEL(II), COPPER(II), COBALT(II), AND ZINC(II) COMPLEXES - CRYSTAL-STRUCTURE OF (3,11-DIBENZYL-7-(2'-PYRIDYLMETHYL)-3,7,11,17-TETRA-AZABICYCLO[11.3.1]-HEPTADECA-1(17),13,15-TRIENE)ZINC(II) PERCHLORATEI
ALCOCK, NW
BALAKRISHNAN, KP
BERRY, A
MOORE, P
READER, CJ
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1988, (04): : 1089 - 1093
[33] STUDIES OF PENDANT ARM MACROCYCLIC LIGANDS .7. SYNTHESIS OF 2 SEXIDENTATE MACROCYCLES BASED UPON A PYRIDINE-CONTAINING TETRA-AZA MACROCYCLE WITH EITHER 2 2-PYRIDYLMETHYL OR 2 1-PYRAZOLYLMETHYL PENDANT COORDINATING ARMS, AND CHARACTERIZATION OF THEIR COBALT(II), NICKEL(II), COPPER(II), AND ZINC(II) COMPLEXES - CRYSTAL-STRUCTURE OF (3,11-DI(2-PYRIDYLMETHYL)-3,7,11,17-TETRA-AZABICYCLO[11.3.1]HEPTADECA-1(17),13,15-TRIENE)NICKEL(II) PERCHLORATE
BALAKRISHNAN, KP
OMAR, HAA
MOORE, P
ALCOCK, NW
PIKE, GA
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1990, (10): : 2965 - 2969
[34] STUDIES OF PENDANT-ARM MACROCYCLIC LIGANDS .5. SYNTHESIS OF 2 PYRIDINE-CONTAINING PENTA-AZA MACROCYCLES WITH SINGLE PYRROLIDINYL PENDANT ARMS AND CHARACTERIZATION OF THEIR NICKEL(II) AND COPPER(II) COMPLEXES - CRYSTAL-STRUCTURE OF PERCHLORATO(7-[2'-(1''-PYRROLIDINYL)ETHYL]-3,7,11,17-TETRA-AZABICYCLO[11.3.1]HEPTADECA-1(17),13,15-TRIENE)NICKEL(II) PERCHLORATEO
ALCOCK, NW
BALAKRISHNAN, KP
MOORE, P
OMAR, HAA
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1987, (03): : 545 - 550
[35] Synthesis and crystal structure determination of cobalt(II) mixed-ligand complex containing 1,10-phenanthroline and 5-(2-carboxybenzyloxy)isophthalic acid: Their biological evaluation viz. DNA/protein binding profile, pBR322 DNA cleavage activity
Tabassum, Sartaj
Ahmad, Musheer
Afzal, Mohd
Zaki, Mehvash
Faizi, Md. Serajul Haque
Ali, Akram
INORGANICA CHIMICA ACTA, 2016, 451 : 216 - 226
[36] Synthesis, cytotoxicity, antibacterial activity and molecular modeling study of new mono, homo and heterobimetallic complexes of palladium (II) with some transition metal ions containing the ligands N-phenyl-N′-(2-thiazolyl)thiourea and Diphosphines Ph2P(CH2)nPPh2 (where n=1-3)
Aziz, Nazk M.
Abdullah, Bayazeed H.
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[37] STUDIES OF PENDANT-ARM MACROCYCLIC LIGANDS .8. SYNTHESIS OF 2 PENTAAZAMACROCYCLES BASED UPON PYRIDINE-CONTAINING TETRAAZAMACROCYCLES WITH A SINGLE PENDANT COORDINATING 2-PYRIDYLMETHYL ARM, AND CHARACTERIZATION OF THEIR NICKEL(II), COPPER(II) AND ZINC(II) COMPLEXES - CRYSTAL-STRUCTURE OF 7-(2'-PYRIDYLMETHYL)-3,7,11,17-TETRAAZABICYCLO[11.3.1]HEPTADECA-1(17),13,15-TRIENEZINC(II) TETRAFLUOROBORATE
GRANT, SJ
MOORE, P
OMAR, HAA
ALCOCK, NW
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1994, (04): : 485 - 489
[38] SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION, AND MAGNETIC-PROPERTIES OF UNUSUAL 3,5-DIALKYL-1,2,4-TRIAZOLE COMPOUNDS CONTAINING N-BRIDGING ISOTHIOCYANATO LIGANDS - X-RAY STRUCTURE OF TRINUCLEAR BIS[(MU-THIOCYANATO-N)BIS(MU-3,5-DIETHYL-1,2,4-TRIAZOLE-N1,N2)BIS(THIOCYANATO-N)(3,5-DIETHYL-1,2,4-TRIAZOLE-N1)NICKEL(II)-N,N1,N1']NICKEL(II) DIHYDRATECT
VANALBADA, GA
DEGRAAFF, RAG
HAASNOOT, JG
REEDIJK, J
INORGANIC CHEMISTRY, 1984, 23 (10) : 1404 - 1408
[39] Ruthenium(II) and ruthenium(IV) complexes containing κ1-P-, κ2-P,O-, and κ3-P,N,O-iminophosphorane-phosphine ligands Ph2PCH2P{=NP(=O)(OR)2}Ph2 (R = Et, Ph):: Synthesis, reactivity, theoretical studies, and catalytic activity in transfer hydrogenation of cyclohexanone
Cadierno, V
Crochet, P
Díez, J
García-Alvarez, J
García-Garrido, SE
Gimeno, J
García-Granda, S
Rodríguez, MA
INORGANIC CHEMISTRY, 2003, 42 (10) : 3293 - 3307

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