Synthesis, structure, DNA and protein binding studies, and cytotoxic activity of nickel(II) complexes containing 3,3-dialkyl/aryl-1-(2,4-dichlorobenzoyl)thiourea ligands

被引：46
|
作者：
Selvakumaran, N. [1 ]
Bhuvanesh, N. S. P. [2 ]
Endo, A. [3 ]
Karvembu, R. [1 ]
机构：
[1] Natl Inst Technol, Dept Chem, Tiruchirappalli 620015, Tamil Nadu, India
[2] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA
[3] Sophia Univ, Dept Mat & Life Sci, Chiyoda Ku, Tokyo 1028554, Japan
来源：
POLYHEDRON | 2014年 / 75卷
关键词：
Acylthiourea; Ni(II) complex; DNA binding; BSA interaction; Cytotoxicity; LIQUID-MEMBRANE TRANSPORT; CRYSTAL-STRUCTURE; BIOLOGICAL-ACTIVITY; ZINC(II) COMPLEXES; IN-VITRO; RUTHENIUM(II) COMPLEXES; ANTITUMOR-ACTIVITY; COBALT COMPLEXES; METAL; PHOTOCLEAVAGE;
D O I：
10.1016/j.poly.2014.03.010
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A new series of nickel(II) complexes of the type [Ni(L)(2)] (1-6) has been synthesized by using the 3,3-dialkyliaryl-1-(2,4-dichlorobenzoyl)thiourea ligands, and characterized by analytical and spectral (NMR, FT-IR and UV-Vis) techniques. The structures of the ligands (HL1, HL2 and HL3) and complexes (2 and 5) have been confirmed by single crystal X-ray diffraction studies. The interaction of the nickel(II) complexes (2-5) with calf thymus (CT) DNA and bovine serum albumin (BSA) protein was investigated using UV-Vis and fluorescence spectroscopic methods. Absorption and emission spectral studies indicate that complex 2 interacts with CT DNA and BSA protein more strongly than the other complexes (3, 4 and 5). Complexes 2 and 5 exhibited good cytotoxicity against A549 and HT29 cell lines at 50 mu M concentration. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：95 / 109
页数：15
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