COMBINED INHIBITION OF TOP1 AND PARP: A NOVEL THERAPEUTIC STRATEGY FOR GBM WITH PTEN DEFICIENCY

被引:0
|
作者
Kim, Olga [1 ]
Butler, Madison [2 ]
Robey, Robert [2 ]
Chari, Raj [3 ]
Sergi, Zach [4 ]
Zhang, Meili [3 ]
Pang, Ying [4 ]
Yu, Guangyang [3 ]
Zhang, Wei [3 ]
Song, Hua [3 ]
Davis, Dionne [3 ]
Wang, Herui [4 ]
Merchant, Mythili [4 ]
Ranjan, Alice [4 ]
Gilbert, Mark [1 ]
Gottesman, Michael [3 ]
Pommier, Yves [5 ]
Wu, Jing [1 ]
机构
[1] NCI, NIH, Neurooncol Branch, Bethesda, MD USA
[2] NCI, NIH, Bethesda, MD USA
[3] NIH, Bethesda, MD USA
[4] NCI, NOB, Bethesda, MD USA
[5] NCI, Bethesda, MD USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
EXTH-63
引用
收藏
页码:223 / 223
页数:1
相关论文
共 50 条
  • [31] HIFA1 inhibition as a therapeutic strategy for overcoming castration resistance in PTEN-deficient prostate cancer
    Terzic, J.
    Abu El Maaty, M.
    Keime, C.
    Jung, M.
    Lutzing, R.
    Metzger, D.
    ANNALS OF ONCOLOGY, 2022, 33 (07) : S548 - S548
  • [32] Combined inhibition of BRD4 and FAK1 as a novel therapeutic strategy for neurofibromatosis type 2 related schwannomas
    Gonzalez, Maria Alejandra
    Kissil, Joseph
    Troutman, Scott
    CANCER RESEARCH, 2023, 83 (08)
  • [33] Investigating Wee1 and Myt1 combined inhibition as a potential cancer therapeutic strategy
    Sokhi, Sargun
    Hadfield, Joanne D.
    Fung, Jeremy
    Chan, Gordon K.
    CANCER RESEARCH, 2023, 83 (07)
  • [34] TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation
    Ho, Jessica Sook Yuin
    Mok, Bobo Wing-Yee
    Campisi, Laura
    Jordan, Tristan
    Yildiz, Soner
    Parameswaran, Sreeja
    Wayman, Joseph A.
    Gaudreault, Natasha N.
    Meekins, David A.
    Indran, Sabarish, V
    Morozov, Igor
    Trujillo, Jessie D.
    Fstkchyan, Yesai S.
    Rathnasinghe, Raveen
    Zhu, Zeyu
    Zheng, Simin
    Zhao, Nan
    White, Kris
    Ray-Jones, Helen
    Malysheva, Valeriya
    Thiecke, Michiel J.
    Lau, Siu-Ying
    Liu, Honglian
    Zhang, Anna Junxia
    Lee, Andrew Chak-Yiu
    Liu, Wen-Chun
    Jangra, Sonia
    Escalera, Alba
    Aydillo, Teresa
    Melo, Betsaida Salom
    Guccione, Ernesto
    Sebra, Robert
    Shum, Elaine
    Bakker, Jan
    Kaufman, David A.
    Moreira, Andre L.
    Carossino, Mariano
    Balasuriya, Udeni B. R.
    Byun, Minji
    Albrecht, Randy A.
    Schotsaert, Michael
    Garcia-Sastre, Adolfo
    Chanda, Sumit K.
    Miraldi, Emily R.
    Jeyasekharan, Anand D.
    TenOever, Benjamin R.
    Spivakov, Mikhail
    Weirauch, Matthew T.
    Heinz, Sven
    Chen, Honglin
    CELL, 2021, 184 (10) : 2618 - +
  • [35] Histone Demethylase Inhibition As a Novel Therapeutic Strategy in Myeloma
    Pawlyn, Charlotte
    Hookway, Edward
    Cain, Peter
    Pliuskys, Laurynas
    Kaiser, Martin F.
    Bright, Michael
    Aronson, Lauren I.
    Murison, Alexander
    Lindow, Morten
    Obad, Susanna
    Oerum, Henrik
    Opperman, Udo
    Morgan, Gareth J.
    Davies, Faith E.
    BLOOD, 2014, 124 (21)
  • [36] Inhibition of NAMPT as a novel therapeutic strategy for infant leukemia
    Somers, Klaartje
    Middlemiss, Shiloh
    Biktasova, Asel
    Karsa, Mawar
    Cheung, Leanna
    Kosciolek, Angelika
    Evans, Kathryn
    Mayoh, Chelsea
    Kees, Ursula R.
    Korotchkina, Lioubov
    Chernova, Olga B.
    Lock, Richard B.
    Gudkov, Andrei V.
    Haber, Michelle
    Norris, Murray D.
    Henderson, Michelle J.
    CANCER RESEARCH, 2017, 77
  • [37] Exportin 1 (XPO1) inhibition alone or in combination as a novel therapeutic strategy in osteosarcoma
    Graves, Laurie
    Rupprecht, Gabrielle
    Altunel, Erdem
    Flamant, Etienne M.
    Rao, Sneha
    Sivara, Dharshan
    Lazarides, Alexander L.
    Hoskinson, Sarah M.
    Sheth, Maya U.
    Cheng, Serene
    Kim, So Young
    Ware, Kathryn E.
    Agarwal, Anika
    Cullen, Mark M.
    Syal, Casey
    Selmic, Laura E.
    Everitt, Jeffrey I.
    McCall, Shannon J.
    Eward, Cindy
    Kashyap, Trinayan
    Maloof, Marie
    Walker, Christopher J.
    Landesman, Yosef
    Wagner, Lars
    Eward, William C.
    Hsu, David S.
    Somarelli, Jason A.
    CANCER RESEARCH, 2022, 82 (12)
  • [38] Microtubule-Targeting Combined with HDAC Inhibition Is a Novel Therapeutic Strategy for Diffuse Intrinsic Pontine Gliomas
    Ehteda, Anahid
    Khan, Aaminah
    Rajakumar, Gayathiri
    Vanniasinghe, Anne S.
    Gopalakrishnan, Anjana
    Liu, Jie
    Tsoli, Maria
    Ziegler, David S.
    MOLECULAR CANCER THERAPEUTICS, 2023, 22 (12) : 1413 - 1421
  • [39] Single-Cell Proteomic Profiling Identifies Combined AXL and JAK1 Inhibition as a Novel Therapeutic Strategy for Lung Cancer
    Taverna, Josephine A.
    Hung, Chia-Nung
    DeArmond, Daniel T.
    Chen, Meizhen
    Lin, Chun-Lin
    Osmulski, Pawel A.
    Gaczynska, Maria E.
    Wang, Chiou-Miin
    Lucio, Nicholas D.
    Chou, Chih-Wei
    Chen, Chun-Liang
    Nazarullah, Alia
    Lampkin, Shellye R.
    Qiu, Lianqun
    Bearss, David J.
    Warner, Steven
    Whatcott, Clifford J.
    Mouritsen, Lars
    Wade, Mark
    Weitman, Steven
    Mesa, Ruben A.
    Kirma, Nameer B.
    Chao, Wei-Ting
    Huang, Tim H-M
    CANCER RESEARCH, 2020, 80 (07) : 1551 - 1563
  • [40] Targeted inhibition of the WEE1 kinase as a novel therapeutic strategy in neuroendocrine neoplasms
    Weindl, Lena
    Atreya, Imke
    Dietrich, Peter
    Neubeck, Sabine
    Neurath, Markus F.
    Pavel, Marianne
    ENDOCRINE-RELATED CANCER, 2021, 28 (09) : 605 - 620