Flow-injection chemiluminescence analysis of lomefloxacin in drugs and biological fluids

被引：4
|
作者：
Li, Liqing [1 ,2 ]
Sun, Hanwen [1 ]
Chen, Xueyan [1 ]
机构：
[1] Hebei Univ, Coll Chem & Environm Sci, Key Lab Analyt Sci & Technol Hebei Prov, Baoding 071002, Hebei Province, Peoples R China
[2] Taishan Univ, Dept Chem, Tai An 271021, Shandong, Peoples R China
来源：
CURRENT ANALYTICAL CHEMISTRY | 2008年 / 4卷 / 02期
关键词：
lomefloxacin; chemiluminescence; fluorescence; flow-injection; pharmaceutical analysis; biological fluids;
D O I：
10.2174/157341108784587849
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A new method was developed for the determination of lomefloxacin by using flow-injection chemiluminescence(CL) based on the reaction of Ce(IV)-sodium thiosulfate-lomefloxacin-sulfuric acid system. The CL conditions were investigated and optimized. The CL intensity was correlated linearly with concentration of lomefloxacin in the range of 1.0x10(-5)similar to 6.0x10(-2) g L-1. The determination limit (3 sigma) is 3x10(-6) g L-1. The relative standard deviation is 1.9% for 11 measurements of 2.0x10(-4) g L-1 lomefloxacin. The method has been applied satisfactorily to determine lomefloxacin in drugs, serum and urine with the recovery of 97.0%similar to 104.5%. The CL mechanism of the system was proposed.
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页码：152 / 156
页数：5
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