Serum fetuin-A levels are inversely associated with clinical severity in patients with primary knee osteoarthritis

被引：9
|
作者：
Xiao, Jie [1 ]
Wang, Xiang-Rui [1 ]
Hu, Kong-Zu [2 ]
Li, Mao-Qiang [3 ]
Chen, Jian-Wei [4 ]
Ma, Tao [4 ]
Li, Zhan-Chun [4 ]
机构：
[1] Shanghai Jiao Tong Univ, Renji Hosp, Dept Anesthesiol, Sch Med, Shanghai 200127, Peoples R China
[2] Anhui Med Univ, Affiliated Hosp 1, Dept Orthopaed Surg, Hefei, Anhui, Peoples R China
[3] Hangzhou First Peoples Hosp, Dept Orthopaed Surg, Hangzhou, Zhejiang, Peoples R China
[4] Shanghai Jiao Tong Univ, Renji Hosp, Dept Orthopaed Surg, Sch Med, Shanghai 200127, Peoples R China
来源：
BIOMARKERS | 2013年 / 18卷 / 01期
关键词：
Osteoarthritis; fetuin-A; serum; biomarker; SYNOVIAL-FLUID; RADIOGRAPHIC SEVERITY; GLYCOPROTEIN/FETUIN-A; ARTHRITIS; OUTCOMES; PROTEIN; PLASMA; HIP;
D O I：
10.3109/1354750X.2012.730551
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The present study aimed to detect serum fetuin-A levels in knee osteoarthritis (OA) patients and to investigate their correlation with clinical severity. We enrolled 215 knee OA patients and 76 healthy controls. We measured serum fetuin-A levels by enzyme-linked immunosorbent assay and assessed the correlation between serum fetuin-A levels and Kellgren-Lawrence grades as well as Western Ontario and McMaster Universities Arthritis Index scores in OA patients. Our results demonstrated that serum fetuin-A levels were independently and negatively correlated with greater clinical severity in OA patients.
引用
收藏
页码：51 / 54
页数：4
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