Serum fetuin-A levels are inversely associated with clinical severity in patients with primary knee osteoarthritis

被引：9

作者：

Xiao, Jie ^{[1
]}

Wang, Xiang-Rui ^{[1
]}

Hu, Kong-Zu ^{[2
]}

Li, Mao-Qiang ^{[3
]}

Chen, Jian-Wei ^{[4
]}

Ma, Tao ^{[4
]}

Li, Zhan-Chun ^{[4
]}

机构：

[1] Shanghai Jiao Tong Univ, Renji Hosp, Dept Anesthesiol, Sch Med, Shanghai 200127, Peoples R China

[2] Anhui Med Univ, Affiliated Hosp 1, Dept Orthopaed Surg, Hefei, Anhui, Peoples R China

[3] Hangzhou First Peoples Hosp, Dept Orthopaed Surg, Hangzhou, Zhejiang, Peoples R China

[4] Shanghai Jiao Tong Univ, Renji Hosp, Dept Orthopaed Surg, Sch Med, Shanghai 200127, Peoples R China

来源：

BIOMARKERS | 2013年 / 18卷 / 01期

关键词：

Osteoarthritis; fetuin-A; serum; biomarker; SYNOVIAL-FLUID; RADIOGRAPHIC SEVERITY; GLYCOPROTEIN/FETUIN-A; ARTHRITIS; OUTCOMES; PROTEIN; PLASMA; HIP;

D O I：

10.3109/1354750X.2012.730551

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The present study aimed to detect serum fetuin-A levels in knee osteoarthritis (OA) patients and to investigate their correlation with clinical severity. We enrolled 215 knee OA patients and 76 healthy controls. We measured serum fetuin-A levels by enzyme-linked immunosorbent assay and assessed the correlation between serum fetuin-A levels and Kellgren-Lawrence grades as well as Western Ontario and McMaster Universities Arthritis Index scores in OA patients. Our results demonstrated that serum fetuin-A levels were independently and negatively correlated with greater clinical severity in OA patients.

引用

页码：51 / 54

页数：4

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