Triterpene Glycosides from the Stems and Leaves of Lonicera japonica

被引：15

作者：

Kuroda, Minpei ^{[1
]}

Shizume, Takaaki ^{[1
]}

Mimaki, Yoshihiro ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Dept Med Pharmacognosy, Sch Pharm, Hachioji, Tokyo 1920392, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2014年 / 62卷 / 01期

关键词：

Lonicera japonica; Caprifoliaceae; triterpene glycoside; ORIENTED CYTOTOXIC ACTIVITY; ENTEROLOBIUM-CONTORTISILIQUUM; AKEBIA-QUINATA; AERIAL PARTS; SAPONINS; BISDESMOSIDES; ROOTS; CONSTITUENTS; THUNB;

D O I：

10.1248/cpb.c13-00592

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new triterpene glycosides, namely lonicerosides F-J (1-5), together with five known ones, were isolated from the stems and leaves of Lonicera japonica. Based on extensive spectroscopic analysis, including two-dimensional (2D)-NMR experiments, and the results of hydrolysis, the structures of the new compounds were determined to be 3 beta-[(beta-D-glucopyranosyl)oxy]-23-hydroxyolean-12-en-28-oic acid O-beta-D-glucopyranosyl(1 -> 6)-[alpha-L-rhamnopyranosyl-(1 -> 2)]-beta-D-glucopyranosyl ester (loniceroside F), 3 beta-[(beta-D-glucopyranosyl) oxy]-23-hydroxyolean-12-en-28-oic acid O-(beta-D-acetyl-beta-n-xylopyranosyl)-(1 -> 6)-[alpha-L-rhamnopyranosyl(1 -> 2)]1-D-glucopyranosyl ester (loniceroside G), 3 beta-[(beta-n-glucopyranosyl)oxy1-23-hydroxyolean-12-en-28oic acid O-(4-O-acetyl-beta-n-xylopyranosyl)-(1 -> 6)-[alpha-L-rhamnopyranosyl-(1 -> 2)]-beta-n-glucopyranosyl ester (loniceroside H), 3 beta-[(alpha-L-arabinopyranosyl)oxy]-23-hydroxyolean-12-en-28-oic acid 19-(3-O-acetyl-beta-nxylopyranosyl)-(1 -> 6)-k-L-rhamnopyranosyl-(1 ->alpha)14-n-glucopyranosyl ester (loniceroside I), and 3 beta-Ka-Lrhamnopyranosyl-(1 -> 2)-beta-n-glucopyranosyl)oxyFolean-12-en-28-oic acid O-alpha-L-rhamnopyranosyl-(1 -> 2)-[beta-xylopyranosyl-(1 -> 6)]-beta-alpha-glucopyranosyl ester (loniceroside J).

引用

页码：92 / 96

页数：5

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