New flavonoid glycosides from the stems and leaves of Astragalus membranaceus

被引：0

作者：

Tan, Jin-Yan ^{[1
]}

Zhao, Jia-Xin ^{[1
]}

Zang, Yun ^{[1
]}

Li, Pei ^{[1
]}

Yang, Si-Qi ^{[1
]}

Li, Xiao-Mao ^{[2
]}

Wang, Ying-Li ^{[1
]}

Cheng, Yan-Gang ^{[1
]}

机构：

[1] Shanxi Univ Chinese Med, Shanxi Modern Chinese Med Engn Lab, Jinzhong 030619, Peoples R China

[2] Jiangsu Food & Pharmaceut Sci Coll, Huaian 223000, Peoples R China

来源：

FITOTERAPIA | 2025年 / 180卷

关键词：

Astragalus membranaceus; Flavonoids; Flavonoid glycosides; Anti-inflammatory activities; CONSTITUENTS;

D O I：

10.1016/j.fitote.2024.106321

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Astragalus membranaceus, a well-known traditional medicine and food, has been extensively studied for its roots. However, comparatively little attention has been paid to its stems and leaves. In this study, we successfully isolated and identified three new flavonoid glycosides (1-3), and eight known analogues ( 4-11 ) from the stems and leaves of A. membranaceus. Notably, compound 10 exhibited significant anti-inflammatory activities in LPSinduced BV2 cells, with IC50 value of 1.11 +/- 0.04 mu M . These findings highlight flavonoids as the key bioactive components present in the stems and leaves of A. membranaceus.

引用

页数：5

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