Synthesis of 3,4-dihydropyrimidin-2(1H)-one viaRetro-Biginellireaction

被引：5
|
作者：
Mondal, Sudipta [1 ]
Mondal, Mohabul A. [1 ]
机构：
[1] Jadavpur Univ, Dept Chem, 188,Raja SC Mallick Rd, Kolkata 700032, India
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 12期
关键词：
DERIVATIVES; DESIGN;
D O I：
10.1002/jhet.4124
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Hydrolytic behavior of 5-acetyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one under alkaline condition has been explored. Mechanistic details are established by LCMS and HPLC. Evidence suggested that the deacetylative benzylidenation proceeds through the retro-Biginelli reaction. The scope of the retro-Biginelli reaction has been explored by the synthesis of substituted DHPs.
引用
收藏
页码：4175 / 4180
页数：6
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