Synthesis of 3,4-dihydropyrimidin-2(1H)-one viaRetro-Biginellireaction

被引：5

作者：

Mondal, Sudipta ^{[1
]}

Mondal, Mohabul A. ^{[1
]}

机构：

[1] Jadavpur Univ, Dept Chem, 188,Raja SC Mallick Rd, Kolkata 700032, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 12期

关键词：

DERIVATIVES; DESIGN;

D O I：

10.1002/jhet.4124

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hydrolytic behavior of 5-acetyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one under alkaline condition has been explored. Mechanistic details are established by LCMS and HPLC. Evidence suggested that the deacetylative benzylidenation proceeds through the retro-Biginelli reaction. The scope of the retro-Biginelli reaction has been explored by the synthesis of substituted DHPs.

引用

页码：4175 / 4180

页数：6

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