The mechanism of action of angiostatin: Can you teach an old dog new tricks?

被引：0
|
作者：
Moser, TL
Stack, MS
Wahl, ML
Pizzo, SV
机构：
[1] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA
[2] Thomas Jefferson Univ, Dept Biochem & Mol Pharmacol, Philadelphia, PA 19107 USA
[3] Northwestern Univ, Sch Med, Dept Cell & Mol Biol, Chicago, IL USA
来源：
THROMBOSIS AND HAEMOSTASIS | 2002年 / 87卷 / 03期
关键词：
angiostatin; plasminogen; endothelial cells; ATP synthase; pH regulation;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
What is angiostatin? In 1994, Folkman and colleagues published a landmark paper describing anti-tumor effects in mice with a purified fragment of plasminogen they named angiostatin (1). Although many papers have been published describing activities of cryptic polypeptides derived from plasminogen fragments, this was the first report which associated plasminogen kringles 1-4 as a suppressor of metastasis development. This review will describe what is known about the mechanism of action of angiostatin from the current literature.
引用
收藏
页码：394 / 401
页数：8
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