The mechanism of action of angiostatin: Can you teach an old dog new tricks?

被引:0
|
作者
Moser, TL
Stack, MS
Wahl, ML
Pizzo, SV
机构
[1] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA
[2] Thomas Jefferson Univ, Dept Biochem & Mol Pharmacol, Philadelphia, PA 19107 USA
[3] Northwestern Univ, Sch Med, Dept Cell & Mol Biol, Chicago, IL USA
关键词
angiostatin; plasminogen; endothelial cells; ATP synthase; pH regulation;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
What is angiostatin? In 1994, Folkman and colleagues published a landmark paper describing anti-tumor effects in mice with a purified fragment of plasminogen they named angiostatin (1). Although many papers have been published describing activities of cryptic polypeptides derived from plasminogen fragments, this was the first report which associated plasminogen kringles 1-4 as a suppressor of metastasis development. This review will describe what is known about the mechanism of action of angiostatin from the current literature.
引用
收藏
页码:394 / 401
页数:8
相关论文
共 50 条
  • [31] Genetics of obesity: can an old dog teach us new tricks?
    Giles S. H. Yeo
    Diabetologia, 2017, 60 : 778 - 783
  • [32] Recognition memory: Can you teach an old dogma new tricks?
    Burwell, Rebecca D.
    Furtak, Sharon C.
    NEURON, 2008, 59 (04) : 523 - 525
  • [33] Altering ethanol pharmacokinetics to treat alcohol use disorder: Can you teach an old dog new tricks?
    Haass-Koffler, Carolina L.
    Akhlaghi, Fatemeh
    Swift, Robert M.
    Leggio, Lorenzo
    JOURNAL OF PSYCHOPHARMACOLOGY, 2017, 31 (07) : 812 - 818
  • [34] Dog Tricks Even You Can Teach Your Pet
    Shonk, Jenny
    LIBRARY JOURNAL, 2022, 147 (10) : 66 - 67
  • [35] Tranexamic Acid in Epistaxis: Can You Teach An Old Drug New Tricks?
    Titus, N.
    Perkins, V.
    Firat, G.
    BRITISH JOURNAL OF SURGERY, 2020, 107 : 82 - 82
  • [37] C-reactive protein in community-acquired sepsis: you can teach new tricks to an old dog
    Salluh, Jorge I. F.
    Lisboa, Thiago
    CRITICAL CARE, 2011, 15 (05):
  • [38] C-reactive protein in community-acquired sepsis: you can teach new tricks to an old dog
    Jorge IF Salluh
    Thiago Lisboa
    Critical Care, 15
  • [39] Vitamin K to reverse the anticoagulant effect of vitamin K antagonists: can you teach an old dog new tricks?
    Douketis, J. D.
    Spyropoulos, A. C.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2010, 8 (03) : 496 - 498
  • [40] You Can('t) Teach an Old Dog New Tricks: Analyzing the Learnability of Manufacturing Software Systems in Older Users
    Arning, Katrin
    Himmel, Simon
    Ziefle, Martina
    HUMAN ASPECTS OF IT FOR THE AGED POPULATION: HEALTHY AND ACTIVE AGING, ITAP 2016, PT II, 2016, 9755 : 277 - 288