Solution-phase reductive cyclization of 2-quinoxalinol analogs: Systematic study of parallel synthesis

被引：20
|
作者：
Wu, Xiang-Hong
Liu, Gang [1 ]
Zhang, Jing
Wang, Zhan-Guo
Xu, Song
Zhang, Suo-De
Zhang, Liang
Wang, Lin
机构：
[1] Chinese Acad Med Sci, Beijing 100050, Peoples R China
来源：
MOLECULAR DIVERSITY | 2004年 / 8卷 / 02期
基金：
国家高技术研究发展计划(863计划);
关键词：
aromatic nitro reduction; m-dinitro benzene; parallel synthesis; 2-quinoxalinol analog; reductive cyclization; solution-phase;
D O I：
10.1023/B:MODI.0000025639.89179.60
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
1,5-Difluoro-2,4-dinitrobenzene starting material was treated via primary and/or secondary substitution with a variety of amino acids or amines and the aromatic m-dinitro groups were then reductively cyclized provide the 2-quinoxalinol analogs. The conditions for 1,5-dialkylamino-2,4-dinitrobenzene reduction have been systematically studied and optimized in solution. Three effective methods are described for the high-throughout generation of 2-quinoxalinol analogs.
引用
收藏
页码：165 / 174
页数：10
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