Solution-phase reductive cyclization of 2-quinoxalinol analogs: Systematic study of parallel synthesis

被引：20

作者：

Wu, Xiang-Hong

Liu, Gang ^{[1
]}

Zhang, Jing

Wang, Zhan-Guo

Xu, Song

Zhang, Suo-De

Zhang, Liang

Wang, Lin

机构：

[1] Chinese Acad Med Sci, Beijing 100050, Peoples R China

来源：

MOLECULAR DIVERSITY | 2004年 / 8卷 / 02期

基金：

国家高技术研究发展计划(863计划);

关键词：

aromatic nitro reduction; m-dinitro benzene; parallel synthesis; 2-quinoxalinol analog; reductive cyclization; solution-phase;

D O I：

10.1023/B:MODI.0000025639.89179.60

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1,5-Difluoro-2,4-dinitrobenzene starting material was treated via primary and/or secondary substitution with a variety of amino acids or amines and the aromatic m-dinitro groups were then reductively cyclized provide the 2-quinoxalinol analogs. The conditions for 1,5-dialkylamino-2,4-dinitrobenzene reduction have been systematically studied and optimized in solution. Three effective methods are described for the high-throughout generation of 2-quinoxalinol analogs.

引用

页码：165 / 174

页数：10

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