Massive restructuring of neuronal circuits during functional reorganization of adult visual cortex

被引:223
|
作者
Keck, Tara [1 ]
Mrsic-Flogel, Thomas D. [1 ]
Afonso, Miguel Vaz [1 ]
Eysel, Ulf T. [2 ]
Bonhoeffer, Tobias [1 ]
Huebener, Mark [1 ]
机构
[1] Max Planck Inst Neurobiol, D-82152 Martinsried, Germany
[2] Ruhr Univ Bochum, Dept Neurophysiol, D-44780 Bochum, Germany
关键词
D O I
10.1038/nn.2181
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The cerebral cortex has the ability to adapt to altered sensory inputs. In the visual cortex, a small lesion to the retina causes the deprived cortical region to become responsive to adjacent parts of the visual field. This extensive topographic remapping is assumed to be mediated by the rewiring of intracortical connections, but the dynamics of this reorganization process remain unknown. We used repeated intrinsic signal and two-photon imaging to monitor functional and structural alterations in adult mouse visual cortex over a period of months following a retinal lesion. The rate at which dendritic spines were lost and gained increased threefold after a small retinal lesion, leading to an almost complete replacement of spines in the deafferented cortex within 2 months. Because this massive remodeling of synaptic structures did not occur when all visual input was removed, it likely reflects the activity-dependent establishment of new cortical circuits that serve the recovery of visual responses.
引用
收藏
页码:1162 / 1167
页数:6
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