Focal activation of neuronal circuits induced by microstimulation in the visual cortex

被引:12
|
作者
Tanaka, Yuta [1 ]
Nomoto, Tomohiro [1 ]
Shiki, Takuya [1 ]
Sakata, Yuya [1 ]
Shimada, Yoshinori [1 ]
Hayashida, Yuki [1 ]
Yagi, Tetsuya [1 ]
机构
[1] Osaka Univ, Grad Sch Engn, Div Elect Elect & Informat Engn, 2-1 Yamada Oka, Suita, Osaka 5650871, Japan
关键词
visual cortex; microstimulation; voltage-sensitive dye; Ca2+-sensitive dye; visual prosthesis; SACCADIC EYE-MOVEMENTS; PYRAMIDAL TRACT CELLS; ELECTRICAL-STIMULATION; INTRACORTICAL MICROSTIMULATION; IN-VIVO; SPATIOTEMPORAL DYNAMICS; PHOSPHENE INDUCTION; STRIATE CORTEX; EXCITATION; PROPAGATION;
D O I
10.1088/1741-2552/ab0b80
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Objective. Microstimulation to the cortical tissue applied with penetrating electrodes delivers current that spreads concentrically around the electrode tip and is known to evoke focal visual sensations, i.e. phosphenes. However, to date, there is no direct evidence depicting the spatiotemporal properties of neuronal activity induced immediately after microstimulation and how such activity drives the subsequent local cortical circuits. Approach. In the present study, we imaged the spatiotemporal distribution of action potentials (APs) directly induced by microstimulation and the subsequent trans-synaptic signal propagation using a voltage- sensitive dye (VSD) and a calcium-sensitive dye (CaSD) in slice preparations of the mouse primary visual cortex. Main results. The directly induced APs were confined to the close vicinity of the electrode tip, and the effective distance of excitation was proportional to the square root of the current intensity. The excitation around the electrode tip in layer IV mainly propagated to layer II/III to further induce the subsequent focal activation in downstream local cortical circuits. The extent of activation in the downstream circuits was restrained by competitive interactions between excitatory and inhibitory signals. Namely, the spread of the excitation to lateral neighbor neurons along the layer II/III was confined by the delayed inhibition that also spread laterally at a faster rate. Significance. These observations indicate that dynamic interactions between excitatory and inhibitory signals play a critical role in the focal activation of a cortical circuit in response to intracortical microstimulation and, therefore, in evoking a localized phosphene.
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页数:17
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