Noninvasive, in vivo imaging of subcortical mouse brain regions with 1.7 μm optical coherence tomography

被引：107

作者：

Chong, Shau Poh ^{[1
]}

Merkle, Conrad W. ^{[1
]}

Cooke, Dylan F. ^{[2
,3
]}

Zhang, Tingwei ^{[1
]}

Radhakrishnan, Harsha ^{[1
]}

Krubitzer, Leah ^{[2
,3
]}

Srinivasan, Vivek J. ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Biomed Engn, Davis, CA 95616 USA

[2] Univ Calif Davis, Dept Psychol, Davis, CA 95616 USA

[3] Univ Calif Davis, Ctr Neurosci, Davis, CA 95616 USA

来源：

OPTICS LETTERS | 2015年 / 40卷 / 21期

基金：

美国国家卫生研究院;

关键词：

2-PHOTON MICROSCOPY; MULTIPLE-SCATTERING; TISSUE; DEPTH; ANGIOGRAPHY; CONTRAST; SKULL;

D O I：

10.1364/OL.40.004911

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

A spectral/Fourier domain optical coherence tomography (OCT) intravital microscope using a supercontinuum light source at 1.7 mu m was developed to study subcortical structures noninvasively in the living mouse brain. The benefits of 1.7 mu m for deep tissue brain imaging are demonstrated by quantitatively comparing OCT signal attenuation characteristics of cortical tissue across visible and near-infrared wavelengths. Imaging of hippocampal tissue architecture and white matter microvasculature are demonstrated in vivo through thinned-skull, glass coverslip-reinforced cranial windows in mice. Applications of this novel platform include monitoring disease progression and pathophysiology in rodent models of Alzheimer's disease and subcortical dementias, including vascular dementia. (C) 2015 Optical Society of America

引用

页码：4911 / 4914

页数：4

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