Field Asymmetric Waveform Ion Mobility Spectrometry Analysis of Proteins and Peptides: A Review

被引：0

作者：

Brown, Lauren J. ^{[1
]}

Creaser, Colin S. ^{[1
]}

机构：

[1] Univ Loughborough, Ctr Analyt Sci, Dept Chem, Loughborough LE11 3TU, Leics, England

来源：

CURRENT ANALYTICAL CHEMISTRY | 2013年 / 9卷 / 02期

关键词：

Gas phase separation; field asymmetric waveform ion mobility spectrometry; FAIMS; differential mobility spectrometry; mass spectrometry; peptide; protein; proteomics; ESI-FAIMS-MS; GAS-PHASE CONFORMERS; MASS-SPECTROMETRY; ELECTROSPRAY-IONIZATION; ATMOSPHERIC-PRESSURE; TRYPTIC PEPTIDES; UBIQUITIN CONFORMERS; AMINO-ACIDS; SEPARATION; PLANAR;

D O I：

暂无

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Field asymmetric waveform ion mobility spectrometry (FAIMS) is a gas-phase atmospheric pressure separation technique that exploits the difference in the mobility of an ion in alternating low and high electric fields applied between two closely spaced electrodes. FAIMS has the potential to simplify mass spectra by separating complex mixtures of ions, including isobaric ions, prior to mass spectral detection. It is a technique that is distinct from both chromatographic and mass-to-charge (m/z) separations. This mini-review discusses the principles of FAIMS separations and instrumentation and the application of FAIMS combined with mass spectrometry for the analysis of peptides and proteins.

引用

页码：192 / 198

页数：7

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