Novel and selective inhibitors of KRASG12D

被引：0
|
作者：
Bhavar, Prashant Kashinath [1 ]
Surampudi, Uday Kumar [1 ]
Sarma, Partha Pratim [2 ]
Shidore, Mahesh Mohan [2 ]
Kshirsagar, Anuj Ramesh [3 ]
机构：
[1] VRise Therapeut Inc, Cambridge, MA USA
[2] VeGen Therapeut Pvt Ltd, Hyderabad, Telangana, India
[3] VeGen Therapeut Inc, Hyderabad, Telangana, India
来源：
CANCER RESEARCH | 2022年 / 82卷 / 12期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
2681
引用
收藏
页数：1
相关论文
共 50 条
  • [41] Identification of novel KRASG12D neoantigen specific TCRs and a strategy to eliminate off-target recognition
    Han, Xiaojian
    Han, Xiaxia
    Hao, Yanan
    Wang, Bozhi
    Li, Luo
    Chen, Siyin
    Zou, Lin
    Huang, Jingjing
    Chen, Tong
    Wang, Wang
    Liu, Shengchun
    Jin, Aishun
    Shen, Meiying
    JOURNAL OF TRANSLATIONAL MEDICINE, 2025, 23 (01)
  • [42] 靶向KRASG12D抑制剂的研究现状
    陈晓睿
    毛国梁
    中南药学, 2023, 21 (06) : 1581 - 1588
  • [43] Cetuximab Enhances the Efficacy of MRTX1133, a Novel KRASG12D Inhibitor, in Colorectal Cancer Treatment
    Kataoka, Masahiro
    Kitazawa, Masato
    Nakamura, Satoshi
    Koyama, Makoto
    Yamamoto, Yuta
    Miyazaki, Satoru
    Hondo, Nao
    Tanaka, Hirokazu
    Soejima, Yuji
    ANTICANCER RESEARCH, 2023, 43 (10) : 4341 - 4348
  • [44] Differences in gynecologic tumor development in Amhr2-Cre mice with KRASG12D or KRASG12V mutations
    Kun, Eucharist H. S.
    Tsang, Yvonne T. M.
    Lin, Sophia
    Pan, Sophia
    Medapalli, Tejas
    Malpica, Anais
    Richards, JoAnne S.
    Gershenson, David M.
    Wong, Kwong-Kwok
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [45] Selective epithelial expression of KRASG12D in the Oncopig pancreas drives ductal proliferation and desmoplasia that is accompanied by an immune response
    Jara, Carlos P.
    Al-Gahmi, Al-Murtadha
    Lazenby, Audrey
    Hollingsworth, Michael A.
    Carlson, Mark A.
    SCIENTIFIC REPORTS, 2025, 15 (01):
  • [46] Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo
    Braun, Benjamin S.
    Archard, Joehleen A.
    Van Ziffle, Jessica A. G.
    Tuveson, David A.
    Jacks, Tyler E.
    Shannon, Kevin
    BLOOD, 2006, 108 (06) : 2041 - 2044
  • [47] Differences in gynecologic tumor development in Amhr2-Cre mice with KRASG12D or KRASG12V mutations
    Eucharist H. S. Kun
    Yvonne T. M. Tsang
    Sophia Lin
    Sophia Pan
    Tejas Medapalli
    Anais Malpica
    JoAnne S. Richards
    David M. Gershenson
    Kwong-Kwok Wong
    Scientific Reports, 10
  • [48] A novel Imidazo[1,2-a]pyridine derivative modulates active KRASG12D through off-like conformational shifts in switch-I and switch-II regions, mimicking inactive KRASG12D
    Ali, Yasir
    Khan, Azmat Ali
    Alanazi, Amer M.
    Fatima, Shabeen
    Kozmon, Stanislav
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 270
  • [49] Targeting the "Undruggable" Driver Protein, KRASG12D, as Potential Therapy in Prostate Cancer
    Kargbo, Robert B.
    ACS MEDICINAL CHEMISTRY LETTERS, 2023, 14 (04): : 365 - 366
  • [50] Angiogenic Property of Mouse Pancreatic Cancer Cells From KrasG12D/p53-/- and KrasG12D/Smad4-/- Transgenic Mice, and Differential Effect of Triptolide on the Tumor Angiogenesis
    Yokoyama, Y.
    Vickers, S. M.
    Saluja, A. K.
    PANCREAS, 2009, 38 (08) : 1065 - 1065
12345